1992 Fiscal Year Final Research Report Summary
Study of vasoconstrictire protein in renal artery
| Project/Area Number |
03670744
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Yamagata University |
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Principal Investigator |
NAKADA Teruhiro Yamagata University Sch of Med, Professor, 医学部, 教授 (50009495)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGOOKA Manabu Yamagata University Sch of Med, Assistant, 医学部, 助手 (20202989)
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| Project Period (FY) |
1991 – 1992
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| Keywords | SHR, SHRSP / non-collagen protein / collagen / renovascular hypertension / phenoxybenzamine / hypertension / norepinephrine / neural factor |
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| Research Abstract |
Synthesis of vascular protein was investigated in renal arteries of stroke-prone and-resistant spontaneously hypertensive rats (SHR, SHRSP). The effect of POB and surgical or pharmacological denervation of the root of the renal and/or mesenteric arteries prevented the development of hypertension of these animals. Incorporation of tritiated proline into the vessels described above were also decreased following the antihypertensive treatments. Positive correlations of ^3H-proline incorporation into the renal or mesenteric artery and systolic blood pressure were remarkably noted.
However, in chronic hypertensive stages, these relationship were not observed.
Based on these findings, vasoconstractive protein, especially non-collagenous protein and collagen appear to possess a vasoconstractive capability. These connective tissue protein was probably mediated neural factors.
In clinical patients, contents of non-collagenous protein and collagen revealed to be high in hypertensive patients.
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