1993 Fiscal Year Final Research Report Summary
Classification of women with hypothalamic progrestargen-negative amenorrhea by nocturnal secretion pattern of serum LH
| Project/Area Number |
03670796
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yokohama City University |
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Principal Investigator |
UEMURA Tsuguo Yokohama City University, School of Medicine, Department of Obstetrics and Gynecology, Associate Professor, 医学部, 助教授 (40046040)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASU Kazuhiro Yokohama City University, School of Medicine, Department of Obstetrics and Gynec, 医学部, 講師 (60171047)
MINAGUCHI Hiroshi Yokohama City University, School of Medicine, Department of Obstetrics and Gynec, 医学部, 教授 (20010176)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Progestagen-negative amenorrhea / LH pulsatile secretion / Melatonin |
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| Research Abstract |
Objectives : The aim of the study was to classify women with progrestagen-negative amenorrhea by diurnal and nocturnal secretion patterns of LH in order to predict prognosis and to know how to manage them.
Study Methods : Blood samples were collected every 10 minutes for 4 hours during day and at night in 33 patients.
Results : Four types of LH pulsatile patterns were observed, that is, no pulse neither during the day nor at night (Group 1), a few pulses only at night (Group 2), only one pulse during the day and several pulses at night (Group 3) and several pulses both during the day and at night (Group 4). Serum E2 was less than 30pg/ml, and serum PRL were not different among 4 groups. The basal level and the pulse amplitude of LH increased from Group 1 to Group 4 in order. Serum level of melatonin at night was markedly high in Group 1 and correlated negatively to LH pulse frequency at night. These data indicates that hypothalamic amenorrhea is return to prepubertal stage. In 6 months, improvement rates of ovarian dysfunction were 0%, 25%, 80% and 67% in Group 1, 2, 3 and 4, respectively. Repeated examination for LH pulsatility at 6 month intervel also revealed improvement of pulsatility related to recovery of ovarian function.
Conclusion : The classification is useful to know the grade of hypothalamic disturbance and to predict prognosis.
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