1993 Fiscal Year Final Research Report Summary
Immunohistochemical study on the vestibular nervous system in senescence accelerated mouse
| Project/Area Number |
03670804
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hirosaki University |
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Principal Investigator |
SHINKAWA Hideichi Hirosaki University School of Medicine Department of Otolaryngology Professor, 医学部, 教授 (90125584)
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| Co-Investigator(Kenkyū-buntansha) |
USAMI Shin-ichi Hirosaki University School of Medicine Department of Otolaryngology Associate Pr, 医学部, 助教授 (10184996)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Vestibule / Vestibular Ganglion / Immunohistochemistry / Senescence Accelerated Mouse / Calcium Binding Protein / calbindin |
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| Research Abstract |
Changes in calbindin-positive/negative cells in the vestibular ganglion of senescence accelerated mouse (SAM) were examined by means of an immunocytochemical method. Calbindin immunoreactivity was found in the larfe ganglion cells, whereas most small ganglion cells showed no immunoreactivity. Calbindin-negative ganglion cells, which are relatively small in size, were decreased in number in SAMP/1 (accelerated senescence pron). These results are in line with the fact that neurons showing higher calbindin may be more resistant to degeneration. The decrease in number of calbindin-negative cells may be due to calcium-mediated cytotoxic events during aging, and may be one of the causes of age-related dysequilibrium.
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