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1993 Fiscal Year Final Research Report Summary

Immunological study of head and neck cancer

Research Project

Project/Area Number 03670820
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTokai University School of Medicine

Principal Investigator

MIYAKE Hirosato  Tokai Univ., E.N.T., Professor., 医学部・耳鼻咽喉科, 教授 (60055720)

Co-Investigator(Kenkyū-buntansha) KIMURA Hideshige  Tokai Univ., E.N.T., Asistant., 医学部・耳鼻咽喉科, 助手 (80054039)
YAMAUCHI Susumu  J.college of N.M.T., Asso.Prof., 医療技術短期大学, 助教授 (50166576)
Project Period (FY) 1990 – 1993
Keywords: Head and neck cancer / Tumor marker / Immunohistochemical detection / IEP / False positive / Anti SCC associated antibody / Commercial antibodies
Research Abstract

A novel squamous cell cancer associated antibody (SCCAAb) was developed, since detection of SCC associated antigens (SCCAA) against the cells and tissues of SCC of head and neck is highly effective for early diagnosis.
SCCAAb was prepared by immunization to rabbit with specific components from pharyngeal SCC cell Line.
Western blot analysis revealed that SCCAA consist of four components from 120KD to 225KD.
Immunological technique by ABC was applied and SCCAAb, commercial anti-bodies ( Involcrin, Keratin, EGF-R, EMA, PKK2, K-ras (P21) ) were used as first antibodies.
Following results were obtained.
Positive number and percent were 34/40 (85%) with SCCAAb, 28/34 (82%) with Involcrine, 29/30 (97%) with Kratin, 26/39 (67%) with EGF-R, 25/37 (68%) with EMA, 26/37 (70%) with PKK2, and 15/37 (1%) with K-ras (P21). False positive number and percent in benign specimens, 11% with SCCAAb, 42% with Involcrine, 85% with Kratin, 34% with EGF-R 28% with EMA, 49% with PKK2 and 18% with K-ras (P21), respectively.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 山内進: "子宮頸部癌の早期細胞診断に関する免疫学的研究" 東海大学短期大学紀要. 27(in press). (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三宅浩郷: "頭頸部癌の免疫化学療法" 日本医事新報. 3552. 13-19 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Susumu Yamauchi: "Immunological Study on cytological detection of Uterine cervical cancer of early stage." Proceeding of the Junior college Tokai Univ.Vol.27(in press). (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirosato Miyake: "Immunological therapy of head and neck cancer." Japan Medical Journal.Vol.3552. 13-19 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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