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1992 Fiscal Year Final Research Report Summary

Molecular biology on the aging from endocrinological and metabolic View points.

Research Project

Project/Area Number 03671140
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionYamanashi Medical University

Principal Investigator

ONAYA Toshimasa  Yamanashi Med Col., Professor, 医学部, 教授 (40020812)

Project Period (FY) 1991 – 1992
KeywordsAging / Vitamin D_3 / Prostacyclin / Parvalbumin / Aldose reductase / Isoliquiritigenin / Atherosclerosis / Endocrinology
Research Abstract

1). We have demonstrated that vitamin D_3 stimulates the production of prostacyclin by vascular smooth muscle cells. As the mechanism involved, we have further shown that 1,25-dihydroxyvitamin D_3 induces the expression of cyclooxygenase mRNA. The data suggest that vitamin D_3 could be an anti-atherosclerotic agent.
2). Using 22-oxa-1,25-dihyroxyvitamin D_3, an analog of vitamin D_3, we have shown that this action of vitamin D_3 is not due to an increase in Ca^<2+> in vivo and in vitro (Life Sci.,51:1105-1112,1992).
3). The polyol pathway is implicated in the pathogenesis of chronic diabetic complications. We have extracted a potent aldose reductase inhibitor from Kampo medicine and identified it as isoliquiritigenin, whose potency is equivalent to ONO-2235. We also found that this substance has an anti-platelet action (Eur.J.Pharmacol., 212: 87-92, 1992).
4). In relation to the polyol pathway, we have demonstrated that aldose reductase mRNA is induced at the physiological concentration of glucose in calf pulmonary artery endothelial cells. This finding probably indicates the correlation between activation of the polyol pathway and reduction of prostacyclin synthesis by endothelial cells, suggesting that elevation of blood glucose could be a trigger for atherosclerosis via the polyol pathway (Diabetologia 35: 730-734, 1992).
5). We have further found an important role of cyclic AMP in diabetic neuropathy (J. Clin. Endocrinol. Metab., 74: 393-398, 1992).

  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] H.Shindo,M.Tawata,T.Onaya: "Cyclic AMP enhances sodium-potassium ATPase activity in the sciatic nerve of streptozotocin-induced diabetic rats." Endocrinology. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Shindo,M.Tawata,T.Onaya: "Reduction of cyclic AMP in the sciatic nerve of streptozotocin-induced diabetic rats and the mechanism involved." J.Endocrinol.(1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Shindo,M.Tawata,K.Aida,T.Onaya: "The role of cyclic AMP and polyol metabolism in diabetic neuropathy." J.Clin.Endocrinol.Metab.74. 393-398 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tawata,K.Aida,T.Noguchi,Y.Ozaki,S.Kume,H.Sasaki,M.Chin,T.Onaya: "The mechanism of antiplatelet action of isoliquiritigenin,a new aldose reductase inhibitor purified from licorice (glycyrrhizae radix)" Eur.J.Pharmacol.212. 87-92 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Inoue,M.Wakasugi,R.Wakao,N.Gan,M.Tawata,Y.Nishii,T.Onaya: "Synthetic analogue of vitamin D_3,22-oxa-1,25-dihydroxyviamin D_3,stimulates the production of prostacyclin by vascular tissues." Life Sci.51. 1105-1112 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Ohtaka,M.Tawata,Y.Hosaka,T.Onaya: "Glucose modulation of aldose reductase mRNA expression and its activity in cultured calf pulmonary artery endothelial (CPAE) cells." Diabetologia. 35. 730-734 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tawata,M.Ohtaka,Y.Hosaka,T.Onaya: "Aldose reductase mRNA expression and its activity are induced by glucose in fetal rat aortic smooth muscle (A10) cells." Life Sci.51. 719-726 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Wakasugi,R.Wakao,M.Tawata,N.Gan,K.Koizumi,T.Onaya: "Bone mineral density in patients with non-insulin-dependent diabetes mellitus-measured by dual energy x-ray adsorptiometry." Bone. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Shindo,M.Tawata,K.Aida,T.Onaya: "Clinical efficacy of a stable prostacyclin analog,Iloprost,in diabetic neuropathy." Prostaglandins. 41. 85-96 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yokomori,Y.Iwasa,K.Aida,M.Inoue,M.Tawata,T.Onaya: "Transcriptional regulation of ferritin messenger RNA levels by insulin in cultured rat glioma cells." Endocrinology. 128. 1474-1480 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Wakasugi,T.Noguchi,M.Inoue,Y.Kazama,M.Tawata,Y.Kanemaru,T.Onaya: "Vitamin D,stimulates the production of prostacyclin by vascular smooth muscle cells." Prostaglandins. 42. 127-136 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Suzuki,N.Hasimoto,F.Shimada,M.Taira,M.Mimura,O.Nozaki,M.Tawata,T.Onaya,H.Makino,S.Yoshida: "Defects in insulin binding and receptor kinase in cells from a woman with type A insulin resistrance and from her family." Diabetologia. 34. 86-92 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ohshima,T.Endo,T.Onaya: "Distribution of parvalbumin immunoreactivity in the human brain." J.Neurol. 238. 320-322 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Wakasigi,R.Wakao,M.Tawata,N.Gan,K.Koizumi,T.Onaya: "Effects of aldose reductase inhibitors on prostacyclin (PGI_2) synthesis by aortic rings from rats with streptozotocin-induced diabetes." Prostagl.Leukotr.Essen.Fatt.Acids. 44. 233-236 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shindo, H., et al.: "Cyclic AMP enhances sodium-potassium ATPase activity in the sciatic nerve of streptozotocin-induced diabetic rats." Endocrinology. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shindo,H., et al.: "Reduction of cyclic AMP in the sciatic nerve of streptozotocin-induced diabetic rats and the mechanism involved." J. Endocrinol.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shindo, H., et al.: "The role of cyclic AMP and polyol metabolism in diabetic neuropathy." J. Clin. Endocrinol. Metab.74. 393-398 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tawata, M., et al.: "The mechanism of antiplatelet action of isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (glycyrrhizae radix)" Eur. J. Pharmacol.212. 87-92 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, M., et al.: "Synthetic analogue of vitamin D_3, 22-oxa-1,25-dihydroxyvitamin D_3, stimulates the production of prostacyclin by vascular tissues." Life Sci.51. 1105-1112 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohtaka, M., et al.: "Glucose modulation of aldose reductase mRNA expression and its activity in cultured calf pulmonary artery endothelial (CPAE) cells." Diabetologia. 35. 730-734 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tawata, M., et al.: "Aldose reductase mRNA expression and its activity are induced by glucose in fetal rat aortic smooth muscle (A10) cells." Life Sci.51. 719-726 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakasugi, M., et al.: "Bone mineral density in patients with non-insulin-dependent diabetes mellitus - measured by dual energy x-ray absorptiometry." Bone. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sindo, H., et al.: "Clinical efficacy of a stable prostacyclin analog, Iloprost, in diabetic neuropathy." Prostaglandins. 41. 85-96 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokomori, N., et al.: "Transcriptional regulation of ferritin messenger RNA levels by insulin in cultured rat glioma cells." Endocrinology. 128. 1474-1480 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakasugi, M., et al.: "Vitamin D_3 stimulates the production of prostacyclin by vascular smooth muscle cells." Prostaglandins. 42. 127-136 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, Y., et al.: "Defects in insulin binding and receptor kinase in cells from a woman with type A insulin resistance and from her family." Diabetologia. 34. 86-92 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshima, T., et al.: "Distribution of parvalbumin immunoreactivity in the human brain." J. Neurol.238. 320-322 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakasugi, M., et al.: "Effects of aldose reductase inhibitors on prostacyclin (PGI_2) synthesis by aortic rings from rats with streptozotocin-induced diabetes." Prostagl. Leukotr. Essen. Fatt. Acids. 44. 233-236 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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