1993 Fiscal Year Final Research Report Summary
Alteration of Cartilagenous Phenotype in Joint Diseases
| Project/Area Number |
03807099
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
AYUTANI Yasutaka Osaka City University Medical School Department of Orthpedics Lectuer, 医学部, 講師 (90200873)
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| Co-Investigator(Kenkyū-buntansha) |
ASADA Kanji Osaka City University Medical School Department of Orthpedics Associate Professo, 医学部, 助教授 (40117924)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Cartilages / Proteoglycan / Collagen / Arthritis / Differentiation / Rhematoid |
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| Research Abstract |
Expression of differentiated phenotype of articular cartilages is strictly related to the function of joints. Alteration of hte phenotype leads to destruction of the cartilage and articular function. Proteoglycan (PG) which is one of the major cartilage-matrix components as well as Type II and other minor collagen show fine aleteraion in quality and quanitity dependently on environment surrounding chondrocytes. The alteration act as signals to chondrocytes and determine functions of them. Therefore, cellular environment would be estimated by examining expression of the differentiated phenotype of chondrocytes and by analyzing cartilag matrix. We studies expression of the differentiated phenotype of chondrocytes in cartilage tissues of disordered human joints, experimental arthritic models (adjuvant induced arthritis of rats and osteoarthritis experimentally induced in rabbit knees) and cultured chondrocytes, particularly based on behaviors of PGs.
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Research Products
(6 results)
