1992 Fiscal Year Final Research Report Summary
ROLES OF CELL GROWTH FACTORS AND CYTOKINES IN POSTEMNOPAUSAL OSTEOPOROSIS
| Project/Area Number |
03807110
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St.Marianna University School of medicine |
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Principal Investigator |
SAGA Masahiko St.Marianna University School of Medicine Department of Obstetrics and Gynecology Associate Professor, 医学部, 助教授 (60081767)
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| Co-Investigator(Kenkyū-buntansha) |
YONAMINE Kyoko The same as above Associate, 医学部, 助手 (20210784)
OHNO Yuko The same as above Associate, 医学部, 助手 (20233231)
KONDO Toshihiko St. Marianna University School of Medicine Department of Obstetrics and Gynecolo, 医学部, 助手 (50215456)
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| Project Period (FY) |
1991 – 1992
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| Keywords | postmenopausal / osteoporosis / growth factor / cytokine |
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| Research Abstract |
Inorder to elucidate the pathogenesis of postmenopausal osteoporosis, serum insulin-like growth factor (IGF)-1 level and the productions of interleukin(IL)-1 and tumor necrosis factor (TNF) by preipheral macrophages were examined, in addition to bone mineral content(BMC) of lumbar spine by quqntitative computed tomography, calcium regulating hormones and bone gla protein(BGP). BMC was significantly decreased along with age in osteoporotics and control group. Serum PTH-M showed apositive regression with age and a negative correlation with BMC in osteoporotics. There were no significant difference between osteoporotics and age-matched normals in serum PTH-intact and PTH-M. Vitamine D metabolites showed significant negative regressions with age and positive correlayions with BCM in osteoporotics. Serum BGP also negatively correlated with BMC in normals. Serum IGF tended to have a significant positive correlation with BMC both in osteoporotics and normals. However, there was no significant difference between osteoporotics and normals. The production of IL tended to be increased in osteoporotics compared to premenopausal normals.
Our studies as well as recent papers suggest that IGF, TNF and IL-1 may control bone metabolism with estrogen action.
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