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1993 Fiscal Year Final Research Report Summary

Comparative study of ATL and HTLV-I related disorders

Research Project

Project/Area Number 04042015
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionKumamoto University

Principal Investigator

TAKATSUKI Kiyoshi  Kumamoto University School of Medcine, 医学部, 教授 (80026830)

Co-Investigator(Kenkyū-buntansha) GESSAIN Antoine  Pasteur Institute, France, ウイルス疫学部, 研究員
FRANCHINI Ge  米国国立衛生研究所, 腫瘍細胞生物学研究部, 研究員
SAKATA Kenmei  Kumamoto University Hospital, 医学部・附属病院, 助手 (60225795)
YAMAGUCHI Kazunari  Kumamoto University Hospital, 医学部・附属病院, 講師 (20128325)
FRANCHINI Genoveffa  National Cancer Institute, USA
Project Period (FY) 1992 – 1993
KeywordsHTLV-I / ATL / HAM / TSP / Uveitis / Mexico / Cuba / Brazil
Research Abstract

Human T lymphotropic virus type I (HTLV-I) has been etiologically associated with a hematological malignancy termed adult T-cell leukemia (ATL) and a chronic neurological disease named HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I infection is endemic in some areas of the world, for example, the southern part of Japan, the Caribbean basin. Many of the ATL patients studied in the USA, the UK, France, and the Netherlands originated from the Caribbean area.
Antibodies against HTLV-I have been detected in 1.2 million people and more than 700 cases of ATL are diagnosed each year in Japan alone. However, in some areas of Central and South America many HAM/TSP patients are observed but not so many ATL patients. Clinical course, ATL subtype, frequencies of hypercalcemia and opportunistic infections, cell morphology, phenotypic profile, and response to treatment seem to be the same for ATL in Japanese, Caribbean, and African patients. One of the differences is in age at onset : the average age is lower for the Caribbean and African than for Japanese ATL patients. And there is a relative paucity of the chronic subtype in Caribbean countries as compared to Japanese cases, while the lymphoma type is more common in Jamaica than in Japan.
The reasons for the differences recorded are not clear. Environmental and genetic influences may be significant in providing different cofactors affecting the manifestations of the disease.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] S.Islas,K.Yamaguchi,K.Takatsuki,et al: "HTLV-I/II infection is absent among risk groups from Mexico City." Vox Sang.64. 57-58 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Blank,K.Yamaguchi,K.Takatsuki,et al: "Report of the fifth international conference on human retrovirology:HTLV." Jpn.J.C.in.Oncol.23. 134-142 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamaguchi,T.Inaoka,K.Takatsuki et al: "HTLV-I,HIV-I and hepatitis B and C viruses in Western Province,Papua New Guinea:A serological survey." Jpn.J.Cancer Res.84. 715-719 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Blank,K.Yamaguchi,K.Takatsuki et al: "Six Colombian patients with adult T-cell leukemia/lymphoma." Leukemia and Lymphoma. 9. 407-412 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamaguchi,K.Takatsuki et al: "Declining trends of HTLV-I prevalence among blood donors in Kumamoto,Japan." J.AIDS. 5. 533-534 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] RA.Gongora-Biachi,K.Yamaguchi,K.Takatsuki et al: "A low prevalence of HTLV-I/II infection among eight population groups from Merida,Yucatan,Mexico." J.AIDS. 5. 104-106 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takatsuki,Y.Hinuma and M.Yoshida: "Advances in adult T-cell leukemia and HTLV-I research" Japan Scientific Societies Press., 261 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Islas, K.Yamaguchi, K.Takatsuki et al.: "HTLV-I/II infection is absent among risk groups from Mexico City" Vox Sang. 64. 57-58 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Blank, K.Yamaguchi, K.Takatsuki et al.: "Report of the fifth international conference on human retrovirology : HTLV" Jpan.J. Clin.Oncol.23. 134-142 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamaguchi, T.Inaoka, K.Takatsuki et al.: "HTLV-I, HIV-I and hepatitis B and C viruses in Western Province, Papua New Guinea : A serological survey" Jpn.J. Cancer Res.84. 715-719 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Blank, K.Yamaguchi, K.Takatsuki et al.: "Six Colombian patients with adult T-cell leukemia/lmphoma" Leukemia and Lymphoma. 9. 407-412 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamaguchi, K.Takatsuki et al: "Declining trends of HTLV-I prevalence among blood donors in Kumamoto, Japan" J. AIDS. 5. 533-534 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] RA.Gongora-Biaehi, K.Yamaguchi, K.Takatsuki et al.: "A low prevalence of HTLV-I/II infection among eight population groups from Merida, Yucatan, Mexico." J. AIDS. 5. 104-106 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takatsuki, Y.Hinuma and M.Yoshida: Japan Scientific Societies Press. Advances in adult T-cell leukemia and HTLV-I research., 1-261 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-02-07  

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