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1993 Fiscal Year Final Research Report Summary

Brain blood flow regulation of the cardiovascular center

Research Project

Project/Area Number 04044141
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionUniversity of Occupational and Environmental Health (1993)
Osaka City University (1992)

Principal Investigator

MAEDA Masanobu  University of Occupational and Environmental Health, Institute of Industrial Ecological Sciences, Department of Systems Physiology, 産業生態科学研究所, 助教授 (80181593)

Co-Investigator(Kenkyū-buntansha) SAPRU Hreday n.  University of Medicine and Dentistry of New Jersey, New Jersey Medical School, S, 医学部・ニュージャージー校, 教授
KRIEGER Abbott J.  University of Medicine and Dentistry of New Jersey, New Jersey Medical School, S, 医学部・ニュージャージー校, 主任教授
NAKAI Masatsugu  National Cardiovascular Center, Research Institute, 研究所, 室長 (90150226)
MATSUURA Shiushi  Osaka City University Medical School, Department of Physiology, 医学部, 教授 (50047007)
Project Period (FY) 1992 – 1993
KeywordsVentrolateral Medulla / Rostral Ventrolateral Medulla / Caudal Ventrolateral Medulla / Cardiovascular Center / Cerebrovascular Circulation / Spinal Cord Circulation / Neural Pathway / Chemical Stimulation
Research Abstract

In urethane-anesthetized, paralyzed and artificially ventilated rats, the neurons in the rostral ventrolateral pressor area(VLPA), origin of the sympathetic nerve activities in the brain stem, were chemically stimulated by microinjection of L-glutamate and the spinal cord blood flow(SCBF) was determined using labeled microspheres. The local SCBFs were significantly decreased and local spinal cord vascular resistances(SCVRs) were significantly increased in all spinal cord regions by unilateral chemical stimulation of the VLPA(n=12). During the chemical stimulation of the VLPA, SCBF increased in response to the changes in arterial PaCO_2, indicating that the reactivity of the spinal cord vasculature was intact(n=5). Microinjections of L-glutamate into an area adjacent to the VLPA had no effect on spinal cord circulation(n=5). These results suggest that the neurons within the VLPA may play a role in the control of spinal cord circulation.
Microinjection of L-glutamate(1.7 nmol) into the ventrolateral medullary depressor area(VLDA) produced a significant(P<0.01) decrease in cerebral blood flow(CBF) and a significant(P<0.01) increase in cerebrovascular resistance(CVR) in the cerebral cortex ipsilateral to the stimulated VLDA side(n=9). Cervical sympathectomy blocked the decrease in CBF and increase in CVR elicited by chemical stimulation of the VLDA (n=10). Depression of the VLPA neurons induced by microinjection of muscimol into the VLPA blocked the CBF decrease and CVR increase responses following chemical stimulation of VLDA(n=11). These results suggest that a vasoconstrictor pathway to control cerebral vessels involves an excitatory projection from the VLDA to the VLPA and the changes in cerebral circulation are mediated by the cervical sympathetic nerves.

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Maeda M: "Spinal cord blood flow decreases following chemical stimulation of the rostral ventrolateral medullary pressor area in anesthetized rats." Journal of the Autonomic Nervous System. 39. 151-158 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai M: "Sympathetic and metabolic mechanisms of the cerebrovasomotor function of the caudal ventrolateral medulla in rats." Neuroscience. 50. 655-662 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田正信: "延髄心臓血管中枢の脳循環調節について" 曽根憲昭,成富博章編 第22回局所脳血流懇話会特別講演集,利根商事,大阪. 33-61 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中井正継: "放射性マイクロスフィアーを用いたラット局所脳血流量の複数回測定法" Du Pont Biotech Update(日本語版). 6. 10-12 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seki M: "Effects of electrical stimulation of motor and cutaneous nerves on spinal cord blood flow." Spine. 18. 1798-1802 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai M: "Parasympathetic cerebrovasodilator center of the facial nerve." Circulation Research. 72. 470-475 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda M: "Medullary cardiovascular center and acute brain swelling." Acta Neurochirurgica Supplment. 60. 168-170 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda M: "Dysfunction of the medullary cardiovascular center may cause acute spinal cord swelling." Acta Neurochirurgica Supplment. 60. 171-173 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda M: "Cerebral vasoconstrictive response produced by chemical stimulation of the caudal ventrolateral medullary depressor area is mediated via the rostral ventrolateral medullary pressor area and the cervical sympathetic nerves." Journal of the Autonomic Nervous System Supplment. in press (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda M: "Regulation of cerebral circulation of the medullary cardiovascular center and its reseptor." Proceeding of 2nd Gauss Symposium(Invited lecture). in press (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai M: "Systemicand regional haemodynamic responses elicited by microinjection of N-Methyl-D-Asparatic acid into the lateral periaquductal grey matter in anaesthetized rats." Neuroscience. 58. 777-783 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai M: "Cerebrovasodilatation of metabolicand non-metabolic origin elicited by chemical stimulation of the lateral periaqueductal grey matter in anaesthetized rats." Neuroscience. 58. 785-791 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai M: "Metabolicand non-metabolic cerebrovasomotor mechanisms operational during hypertensive states of different origins in rats." Journal of the Autonomic Nervous System. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morino M: "Effects of microinjection of N-Methyl-D-Asparatic acid into the neucleus tractus solitarii on cerebral blood flow in anesthetised rats." Journal of the Autonomic Nervous System. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田正信: "脊髄循環-特に脳幹部及び末梢神経による循環調節-" 日獨医報. 39(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小山素麿: "変形性頚椎症はなぜ神経症状をきたすのか" 日獨医報. 39(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中井正継: "循環生理機能と病態 V.臓器循環 2-脳循環 A.脳循環に対する神経性調節" 二宮石雄,菅弘之(編),南江堂,東京, 7 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda,M., Krieger,A.J., Nakai,M. and Sapru,H.N.: "Spinal cord blood flow decreases following chemical stimulation of the rostral ventrolateral medullary pressor area in anesthetized rats." J.Auton.Nerv.Syst.39. 151-158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai,M., Tamaki,K. and Maeda,M.: "Sympathetic and metabolic mechanisms of the cerebrovasomotor function of the caudal ventrolateral medulla in rats." Neuroscience.50. 655-662 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai,M., Tamaki,K., Ogata,J., Matsui,Y. and Maeda,M.: "Parasympathetic cerebrovasodilator center of the facial nerve." Circulation Res.72. 470-475 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seki,M. and Maeda,M.: "Effects of electrical stimulation of motor and cutaneous nerves on spinal cord blood flow." Spine.18. 1798-1802 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,M., Takachi,T., Nakai,M., Krieger,A.J. and Sapru,H.N.: "Medullary cardiovascular center and acute brain swelling." Acta Neurochirurgica Suppl.60. 168-170 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,M., Nakai,M., Krieger,A.J. and Sapru,H.N.: "Dysfunction of the medullary cardiovascular center may cause acute spinal cord swelling." Acta Neurochirurgica Suppl.60. 171-173 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,M., Hayashida,Y., Nakai,M., Krieger,A.J., Sapru,H.N.: "Cerebral vasoconstructive response produced by chemical stimulation of the caudal ventrolateral medullary depressor area is mediated via the rostral ventrolateral medullary pressor area and the cervical sympathetic nerves." J.Auton.Nerv.Syst.Suppl.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,M.: "Regulation of cerebral circulation of the medullary cardiovascular center and its receptor." Proceeding of 2nd Gauss Symposium.(Invited lecture). in press (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai,M. and Maeda,M.: "Systemic and regional hemodynamic responses elicited by microinjection of N-Methyl-D-Asparatic acid into the lateral periaqueductal gray matter in anesthetized rats." Neuroscience.58. 777-783 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai,M. and Maeda,M.: "Cerebrovasodilatation of metabolic and non-metabolic origin elicited by chemical stimulation of the lateral periaqueductal gray matter in anesthetized rats." Neuroscience.58. 785-791 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai,M., Tamaki,K., Ogata,J. and Maeda,M.: "Metabolic and non-metabolic cerebrovasomotor mechanisms operational during hypertensive states of different origins in rats." J.Auton.Nerv.Syst.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morino,M., Maeda,M., Nakai,M., Krieger,A.J., and Sapru,H.N.: "Effects of microinjection of N-methyl-D-aspartic acid into the nucleus tractus solitary on cerebral blood flow in anesthetized rats" J.Auton.Nerv.Syst.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morino,M., Maeda,M., Nakai,M., Krieger,A.J., and Sapru,H.N.: "Effects of microinjection of N-methyl-D-aspartic acid into the nucleus tractus solitary on cerebral blood flow in anesthetized rats" J.Auton.Nerv.Syst.(in press). (1994)"besides above papers four articles(in Japanese) and one chapter in book(in Japanese)"

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-02-07  

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