1992 Fiscal Year Annual Research Report

がん治療における放射線の時間的線量配分に関する研究

Research Project

Project/Area Number	04151018
Research Institution	The University of Tokyo
Principal Investigator	鈴木紀夫東京大学, 医学部(医), 教授 (10010050)
Co-Investigator(Kenkyū-buntansha)	新部英男群大, 医学部, 教授 (90008293) 坂本澄彦東北大, 医学部, 教授 (20014029) 小野公二京大原子炉実験所, 附属原子炉医療基礎研究施設, 教授 (90122407) 小川恭弘高知医大, 医学部, 助教授 (90152397) 安藤興一放医研, 臨床研究部, 室長 (00159526)
Keywords	マウス移植腫瘍 / 先行指標 / 低酸素性細胞 / Ki,BUdR Indeces / 分割照射 / 放射線感受性 / Low dose Survival Curve / がん転移
Research Abstract	TumorにおけるHypoxic cellの放射線抵抗性に関する研究は、重要な課題の一つである。Reoxygenationの過程で、活性酸素により、40-50分で急速な細胞死が起こる可能性のあることが骨肉種細胞系MG-63細胞で示された。これは、心筋におけるreperfusion injuryに相当するかもしれない。先行指標に関して本年は低線量域のSurvival CurveやKi、BUdR他による腫瘍増殖Indecesが、頭頚部及び子宮癌症例、ヒト腫瘍細胞のin vitro培養およびin vivo(ヌードマウス)系で検討されたが、分割照射にどのように有用か結論に到達しなかった。難治性の進行肺癌および神経膠芽腫症例において小線量分割照射(70-80Gy)や不均等分割照射、また、肺類表皮癌症例でスプリット照射が、症状の寛解効果、生存率向上、障害の軽減などについて通常分割照射と比較検討され、有効な場合の可能性が示された。転移の実験腫瘍系における放射線照射の転移への影響に関しては、尾静脈への腫瘍細胞の静注後形成される肺結節計測法において、5-6Gyの全身照射で肺結節数の増加が起こる腫瘍があることが分かっている(例えばC3H/HeJマウスに移植したFSA1233腫瘍細胞)が、その場合でも1Gy×5回に分割照射するとその増加効果はなくなり、また20cGyの低線量照射は逆に抑制効果を示した。下肢に移植し、肺転移数を計測する自然転移系(NFSA2ALM1 Fibrosarcoma,NR-S1 Squamous Cell Carcinoma)では全身または胸部照射を1回でまたは5回分割して与えても、いずれの場合も肺結節数の増加はなかった。以上3種のマウス腫瘍系による結果は胸部や腫瘍局所の分割照射によって肺転移が増加することはないことを示すと結論された。

Research Products
(17 results)

All Other

All Publications (17 results)

[Publications] K.Sakata: "Linear quadratic model of radiocurability on multicellular spheroids of human lung adenocarcinoma LCT1 and mouse fibrosarcoma FSA." Int.J.Radiat.Biol.61(29). 269-274 (1992)
[Publications] S.Kobayashi: "Effects of 2-mercaptopropionylglycine on the development of X-ray-induced cataract in rats." Current Eye Research. 11(11). 1099-1103 (1992)
[Publications] H.Majima: "Interaction Between the Kinetics of Thermotolerance and Effect of Cis-diamminedichloroplatinum(II)or Bleomycin given at 37 C or 43 C." Int.J.Hyperthermia. 8(4). 431-442 (1992)
[Publications] H.Majima: "Effect of hyperthermia on the alpha and beta components (alpha-beta ratio)of the cell survival curves following photons or neutrons." Int.J.Hyperthermia. (1993)
[Publications] S.Yamada: "Low-dose rate telecobalt therapy as a boost therapy against esophageal carcinoma." Cancer. 69(5). 1099-1103 (1992)
[Publications] Y.Hosoi: "Effect of recombinant human granurocyte colony-stimulating factor on survival in lethally irradiated mice." Acta Oncologica. 31(1). 59-63 (1992)
[Publications] 高井良尋: "局所および局所リンパ節再乳癌の放射線治療と予後因子の検討" 臨床放射線. 37(6). 661-667 (1992)
[Publications] T.Inomata: "Effects of radiation therapy and Sizofiran (SPG)in Lewis lung cancar cell-inoculated C57BL/6 mice.1.The suppression of tumor growth and lung metastasis." Radiosensitization Newsletter. 11(3). 11-13 (1992)
[Publications] T.Inomata: "Effects of radiation therapy and Sizofiran(SPG)in Lewis lung cancer cell-inoculated C57BL/6 mice.2.The relationship between anti-tumor effects,and the infiltration grade and subpopulation of tumor infiltrated monocytes." Radiosensitization Newsletter. 11(4). 11-15 (1992)
[Publications] Y.Ogawa: "Changes in the Ki-67 labeling rates of head and neck squamous cell carcinomas during preoperative radiation therapy." Oncology. 49. 450-453 (1992)
[Publications] N.Mitsuhashi: "Radiation therapy for malignant tumors in patients 80 years of age or older." J.Jpn.Soc.Ther.Radiol.Oncol.4(3). 179-187 (1992)
[Publications] M.Kojima: "Malignant lymphoma of the nasal cavity and paranasal sinuses,a clinicopathological and immunohistochemical study." Acta Pathologica Japonica. 42(5). 333-338 (1992)
[Publications] K.Hayakawa: "Radiation therapy for stage I-III epidermoid carcinoma of the lung." Lung Cancer. 8(3,4). 213-223 (1992)
[Publications] K.Hayakawa: "Radiation therapy for stage I and II lalyngial cancer using 10MV X-rays or cobalt-60 γ-rays." Radiation Medicine. 10(5). 199-205 (1992)
[Publications] M.Mukai: "Effect of combined therapy,radiation and two local administrations of OK-432,on a murine fibrosarcoma (NFSa)." J.Jpn.Soc.Ther,Radiol.Oncol.4. 77-84 (1992)
[Publications] K.Ando: "Nonlinear survival curves for cells of solid tumors after large doess of fast neutrons and γ-rays." Radiat.Res.131. 157-161 (1992)
[Publications] T.Jibu: "Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma." Clin.Exptl.Metastasis. (1993)

1992 Fiscal Year Annual Research Report

がん治療における放射線の時間的線量配分に関する研究

Principal Investigator

鈴木 紀夫 東京大学, 医学部(医), 教授 (10010050)

Research Products

[Publications] K.Sakata: "Linear quadratic model of radiocurability on multicellular spheroids of human lung adenocarcinoma LCT1 and mouse fibrosarcoma FSA." Int.J.Radiat.Biol.61(29). 269-274 (1992)

[Publications] S.Kobayashi: "Effects of 2-mercaptopropionylglycine on the development of X-ray-induced cataract in rats." Current Eye Research. 11(11). 1099-1103 (1992)

[Publications] H.Majima: "Interaction Between the Kinetics of Thermotolerance and Effect of Cis-diamminedichloroplatinum(II)or Bleomycin given at 37 C or 43 C." Int.J.Hyperthermia. 8(4). 431-442 (1992)

[Publications] H.Majima: "Effect of hyperthermia on the alpha and beta components (alpha-beta ratio)of the cell survival curves following photons or neutrons." Int.J.Hyperthermia. (1993)

[Publications] S.Yamada: "Low-dose rate telecobalt therapy as a boost therapy against esophageal carcinoma." Cancer. 69(5). 1099-1103 (1992)

[Publications] Y.Hosoi: "Effect of recombinant human granurocyte colony-stimulating factor on survival in lethally irradiated mice." Acta Oncologica. 31(1). 59-63 (1992)

[Publications] 高井 良尋: "局所および局所リンパ節再乳癌の放射線治療と予後因子の検討" 臨床放射線. 37(6). 661-667 (1992)

[Publications] T.Inomata: "Effects of radiation therapy and Sizofiran (SPG)in Lewis lung cancar cell-inoculated C57BL/6 mice.1.The suppression of tumor growth and lung metastasis." Radiosensitization Newsletter. 11(3). 11-13 (1992)

[Publications] T.Inomata: "Effects of radiation therapy and Sizofiran(SPG)in Lewis lung cancer cell-inoculated C57BL/6 mice.2.The relationship between anti-tumor effects,and the infiltration grade and subpopulation of tumor infiltrated monocytes." Radiosensitization Newsletter. 11(4). 11-15 (1992)

[Publications] Y.Ogawa: "Changes in the Ki-67 labeling rates of head and neck squamous cell carcinomas during preoperative radiation therapy." Oncology. 49. 450-453 (1992)

[Publications] N.Mitsuhashi: "Radiation therapy for malignant tumors in patients 80 years of age or older." J.Jpn.Soc.Ther.Radiol.Oncol.4(3). 179-187 (1992)

[Publications] M.Kojima: "Malignant lymphoma of the nasal cavity and paranasal sinuses,a clinicopathological and immunohistochemical study." Acta Pathologica Japonica. 42(5). 333-338 (1992)

[Publications] K.Hayakawa: "Radiation therapy for stage I-III epidermoid carcinoma of the lung." Lung Cancer. 8(3,4). 213-223 (1992)

[Publications] K.Hayakawa: "Radiation therapy for stage I and II lalyngial cancer using 10MV X-rays or cobalt-60 γ-rays." Radiation Medicine. 10(5). 199-205 (1992)

[Publications] M.Mukai: "Effect of combined therapy,radiation and two local administrations of OK-432,on a murine fibrosarcoma (NFSa)." J.Jpn.Soc.Ther,Radiol.Oncol.4. 77-84 (1992)

[Publications] K.Ando: "Nonlinear survival curves for cells of solid tumors after large doess of fast neutrons and γ-rays." Radiat.Res.131. 157-161 (1992)

[Publications] T.Jibu: "Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma." Clin.Exptl.Metastasis. (1993)

鈴木紀夫東京大学, 医学部(医), 教授 (10010050)

[Publications] 高井良尋: "局所および局所リンパ節再乳癌の放射線治療と予後因子の検討" 臨床放射線. 37(6). 661-667 (1992)