1995 Fiscal Year Annual Research Report

中枢シナプスの分子生物学

Research Project

Project/Area Number	04267102
Research Institution	The University of Tokyo
Principal Investigator	三品昌美東京大学, 医科部(医), 教授 (80144351)
Co-Investigator(Kenkyū-buntansha)	伊藤正男理化学研究所, 国際フロンティア研究システム, システム長 (90009887) 津本忠治大阪大学, 医学部, 教授 (50028619) 阿部輝雄新潟大学, 脳研究所, 助教授 (50010103) 吉岡亨早稲田大学, 人間科学部, 教授 (70046027) 清水孝雄東京大学, 医科部(医), 教授 (80127092)
Keywords	脳 / 中枢シナプス / 記憶 / 学習 / シナプス可塑性 / シナプス機能分子 / 分子生物学
Research Abstract	高次の生理機能を担う中枢シナプスにおける情報伝達の素過程および調節を分子レベルで明らかにすることを目的に、重点領域研究「中枢シナプスの分子生物学」では三つの研究計画班を、中枢シナプスの基本要素であるシナプス後部、シナプス前部および両者のクロストークに対応させて組織し、分子生物学、生理学、薬理学、解剖学、生化学、発生工学などの研究分野を包含する統合的研究を推進した結果、グルタミン酸受容体をはじめとする多くの重要な中枢シナプス機能分子の実体とその生理機能を解明し、その成果がNatureなどに公表され、多くが世界をリ-ドするレベルにあることが示されている。本研究は、平成4年度から平成6年度に渡って遂行している重点領域研究「中枢シナプスの分子生物学」の研究成果をとりまとめ、さらに研究成果を広く公開することを目的とする。研究成果のとりまとめとして、本重点領域研究によって得られた主要な成果を要約し、さらにすべての計画班員および公募班員について、1.研究目的、2.研究成果の要約、3.研究成果、4.研究成果の意義と展望、5.発表論文、という形式で各自の研究成果を記述することにより、重点領域研究「中枢シナプスの分子生物学」研究成果報告書(485頁)を作成した。さらに、班員による代表的な原著論文を取り上げ、重点領域研究「中枢シナプスの分子生物学」論文集(約560頁)を作成した。同時に、各班員の研究成果を最もよく表している和文総説をとりまとめ、重点領域研究「中枢シナプスの分子生物学」和文総説集(約480頁)を作成した。また、IBRO神経科学世界大会のサテライトシンポジウムをはじめ学会においてシンポジウムを開催し、広く研究成果を公開した。

Research Products

(71 results)

All Other

All Publications (71 results)

[Publications] Ikeda,K.: "Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel." Mol.Brain Res.33. 61-71 (1995)
[Publications] Mori,H.: "Structure and function of the NMDA receptor channel." Neuropharmacology. 34. 1219-1237 (1995)
[Publications] Morita,T.: "Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain." Neurosci.Lett.198. 131-134 (1995)
[Publications] Kashiwabuchi,N.: "Impairment of motor coordination,Purkinje cell synapse formation and cerebellar long-term depression in GluRδ2 mutant mice." Cell. 81. 245-252 (1995)
[Publications] Sakimura,K.: "Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit." Nature. 373. 151-155 (1995)
[Publications] Kawamoto,S.: "N-linked glycosylation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA)-selective glutamate receptor channel α2 subunit is essential for the acquisition of ligand-binding activity." J.Neurochem.64. 1258-1266 (1995)
[Publications] Watanabe,S.: "Stable production of mutant mice from double gene converted ES cells with puromycin and neomycin." Biochem.Biophys.Res.Commun.213. 130-137 (1995)
[Publications] Hirano,T.: "Suppression of LTD in cultured purkinje cells deficient in the glutamate receptor δ2 subunit." NeuroReport. 6. 524-526 (1995)
[Publications] Yamakura,T.: "Different effects of propofol on various AMPA-,kainate-and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes." Neurosci.Lett.188. 187-190 (1995)
[Publications] Watanabe,M.: "Cerebellum of adult reeler mutant mouse contains two Purkinje cell populations with respect to gene expression for the N-methyl-D-aspartate receptor channel." Neurosci,Res.22. 335-345 (1995)
[Publications] Takayama,C.: "Light-and electron-microscopic localization of the glutamate receptor channel δ2 subunit in the mouse Purkinje cell." Neurosci,Lett.188. 89-92 (1995)
[Publications] Kawamoto,S.: "Expression and characterization of the ζ1 subunit of the N-methyl-D-aspartate(NMDA)receptor channel in a Baculovirus system." Mol.Brain Res.30. 137-148 (1995)
[Publications] Watanabe,T.: "Prostaglandin F2a stimulates formation of the p21ras-GPT complex and mitogen-activated protein kinase activity in NIH-3T3 cells via a Gq-protein-coupled pathway,..." J.Biol.Chem.270. 8894-8990 (1995)
[Publications] Honda,Z.: "Gq Pathway desensitizes chemotactic receptor-induced calcium signaling viainositol trisphosphate receptor dowm-regulation." J.Biol.Chem.270. 4840-4844 (1995)
[Publications] M.Nakamura: "Identification of two isoforms of mouse neuropeptide Y-Y1receptor generated by alternative splicing.Isolation,genomic structure,and functional expression of the receptors." J.Biol.Chem.270. 30101-30108 (1995)
[Publications] Mutoh,H.: "Tissue-specific response of the human platelet-activating factor receptor gene to retinoic acid and thyroid hormone is directed by two distinct promoters." Proc.Natl.Acad.Sci.U.S.A.in press.
[Publications] Yokomizo,T.: "CDNA cloning,expression,and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase." J.Biol.Chem.271. 2844-2850 (1996)
[Publications] Mori,M.: "Predominant expression of platelet-activating factor receptor in the rat brain microglia." J.Neurosci.(in press).
[Publications] Bito,H.: "Platelet-activating factor(PAF)receptor in rat brain PAF mobilizes intracellular Ca^<2+>in hippocampal neurons." Neuron. 9. 285-294 (1992)
[Publications] Yokomizo,T.: "Enzymatic inactivation of leukotriene B_4 by a novel enzyme found in the porcine kidney.Purification and properties of leukotriene B_4 12-hydroxy-dehydrogenase." J.Biol.Chem.268. 18128-18135 (1993)
[Publications] Honda,Z.: "Transfected platelet-activating factor receptor activates mitogen-activated protein(MAP)kinase and MAP kinase kinase in Chinese hamster ovary cells." J.Biol.Chem.269. 2307-2315 (1994)
[Publications] Bito,H.: "Functional coupling of a rat hippocampal somatostatin receptor to inhibition of adentylate cyctase,activation of arachidonate release and mitogen-activated(MAP)kinase." J.Biol.Chem.269. 12727-12730 (1994)
[Publications] Takano,T.: "Role of cytoplasmic-tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization." J.Biol.Chem.269. 22453-22458 (1994)
[Publications] Ferby,I.: "Wormannin inhibits mitogen-activated protein kinase・induced by platelet-activating factor in guinea-pig neutrophils." J.Biol.Chem.269. 30485-30488 (1994)
[Publications] Kim,C.S.: "Alzhcimcr and β-amyloid-treated fibroblasts demonstratc a dccrease in a memory associated GTP-binding protcin,Cp20" Proc.Natl.Acad.Sci.USA. 92. (1995)
[Publications] Inoue,H.: "A novel function for nucleoside diphosphate kinase in Drosophila" Biochem.Biophys.Res.Comm.(in press). 3060-3064
[Publications] Olds,J.L.: "Imaging protcin kinase Cactivation in living sea urchin eggs after fertilization." Develop.Biol.(in press).
[Publications] Hirata,K.: "Baclofen inhibits GABAergic transmission after treatment with type-specific calcium channel blockers in cultured rat hippocampal neurons." Neurosci.Lett.187. 208-208 (1995)
[Publications] Kamiya,H.: "Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fiber synapse." J.Physiol.(in press).
[Publications] Sekiyama,N.: "Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes" British Journal of Pharmacology. (in press).
[Publications] Otsu,Y.: "Hebbin induction of LTP in visual cortex:A perfotated patch clamp syudy in cultured neurons." J.Neurophysiol.74. 2437-2444 (1995)
[Publications] Sato,H.: "Machanisms underlying direction sdectivity of neurons in the primary visual cortex of the macaque." J.Neurophysiol.74. 1382-1394 (1995)
[Publications] Torii,N.: "An inhibitor for calcineurin,FK506 blocks induction of long-term depression in rat visual cortex." Neurosci.Lett.185. 1-4 (1995)
[Publications] Sato,H.: "Broad-tuned chromatic inputs to color-selective neurons in the monkey visual cortex." J.Neurophysiol.72. 163-168 (1994)
[Publications] Funauchi,M.: "Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase.calcineurin,on induction of long-term potentiation in rat visual cortex." Neurosci.Res.19. 269-278 (19954)
[Publications] Yoshimura,Y.: "Deopendence of LTP induction on postsynaptic depolarization:A perforated patch clamp study in visual cortical slices of young rats." J.Neurophysiol.71. 1638-1645 (1994)
[Publications] Ayako Ajima: "A unique role of protein phosphatases in cerebellar long-term depression" Neuro Report. 6. 297-300 (1995)
[Publications] Kazutoshi Nakazawa: "Transient and persistent phosphorylation of AMPA-Type Glutamate Receptor Subunits in Cerebellar Purkinje Cells" Neuron. 15. 697-709 (1995)
[Publications] K.Nakazawa: "Antibody specific for phosphorylated AMPA-Type glutamate receptors at Glur2 Ser-696" Neuroscience Research. 24. 75-86 (1995)
[Publications] Nagai,Y.: "The birth of glycobiology and glycotechnology;Studies of the third chain chain of Life" RIKEN Review. 8. 1-2 (1995)
[Publications] Ohashi,Y.: "Adventures in glyco-mass-stectrometry.Seeking for a better method." RIKEN Review. 8. 45-46 (1995)
[Publications] Nagai,Y.: "Functional roles of gangliosides in bio-signaling." Behavioural Brain Res.66. 99-104 (1995)
[Publications] Ii,T.: "Structural elucidation of underivatized gangliosides by electrospray-ionization tandem mass spectrometry(ESIMS/MS)" Carbohydrate Res.273. 27-40 (1995)
[Publications] Ii,T.: "Fast atom bombardment and electrospray ionization tandem mass spectrometry of sulfated lewis" J.Biochem.118. 526-533 (1995)
[Publications] Nakanishi,S.: "Second-order neurons and receptor mechanisms in visual and olfactory information processing" Trends in Neurosciences. 18. 359-364 (1995)
[Publications] Masu,M.: "Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene" Cell. 80. 757-765 (1995)
[Publications] Kabe,H.: "Synaptic mechanisms of oifactory recognition memory" Reviews in the Neurosciences. 6. 125-141 (1995)
[Publications] Yokoi,M: "Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb" Proceedings of the National Academey of Sciences of the United Statesof America. 92. 3371-3375 (1995)
[Publications] Tokita,Y.: "Characterization of excitatory amino acid neurotoxicity in N-methy1-D-aspartate receptor-deficient mouse cortical neuronal cells" European Journal of Neuroscience. (in press).
[Publications] Moriyoshi,K.: "Labeling living neurons by adenovirus-mediated gene transfer of modified membrane-targeted green fluorescent protein" Neuron. (in press).
[Publications] M.Kasai: "Effects of KC1 concentrations on gating properties of calcium release channels in sarcoplasmic reticulum vesicles." J.Biochem.117. 251-256 (1995)
[Publications] T.Ide: "An anion channel from transverse tubular membranes incorporated into planar bilayers." Biochim.Biophys.Acta.1237. 115-120 (1995)
[Publications] N.Yamaguchi: "DIDS binding 30-kDa protein regulates the calcium release channel in the sarcoplasmic reticulum." Biochem.Biophys.Res.Commun.210. 648-653 (1995)
[Publications] M.Ohkura: "Calsequestrin is essential for the Ca^<2+> release induced by miotoxin α in skeletal muscle sarcoplasmic reticulum." Can.J.Physiol.Pharmacol.73. 1181-1185 (1995)
[Publications] S.B.Sato: "Enhancement of fluid-phase endocytosis by high-calcium medium and factors" Cell Physiology. (in press).
[Publications] Hirota,J.: "Kinetics of calcium release by immunoaffinity-purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles." J.Biol.Chem.270(32). 19046-19051 (1995)
[Publications] Ogawa,M.: "The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons." Neuron. 14. 899-912 (1995)
[Publications] Fukuda,M.: "Functional diversity of C2 domains of synaptotagmin family." J.Biol.Chem.270(44). 26523-26527 (1995)
[Publications] Fukuda,M.: "Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10708-10712 (1995)
[Publications] Mikoshiba,K.: "Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10703-10707 (1995)
[Publications] Monkawa,T.: "Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits." J.Biol.Chem.270. 14700-14704 (1995)
[Publications] Matsumoto,M.: "Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor." Nature. 379. 168-171 (1996)
[Publications] Aruga,J.: "The mouse zic gene family(Homologues of the Drosophila pair-rule gene odd paired." J.Biol.Chem.271. 1043-1047 (1996)
[Publications] S.Mochida: "Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not ca ^<2+> channel activity." Neuroscience. 65. 905-915 (1995)
[Publications] K.Ibaraki: "Identification of four different forms of syntaxin 3" Biochem.Biophys.Res.Commun.221. 997-1005 (1995)
[Publications] H.Tokumaru: "A calcium channel from the presynaptic nerve terminal of the Narke japonica electric organ contains a non-N-type α_2δ subunit." J.Neurochemistry. 651. 831-836 (1995)
[Publications] T.Ishizuka: "Synaphin:a protein associated with the docking/fusion complex in presynaptic terminals." Biochem.Biophys.Res.Commun.213. 1107-1114 (1995)
[Publications] 吉岡亮: "情報生物学シリーズ4「シナプス伝達のダイナミクス」" 培風館, 146 (1995)
[Publications] Yagai,Y.: "″Cellular Biology of Gangliosides″in Biology of the Slalic Acids(eds.by Rosenberg,A.)" Plenum Press,New York, 197-241 (1995)
[Publications] Hirota Junji,: "Genes for development,cell growth and infectious diseases(A decade of Pasteur Riken collaboration)" John Libbey EUROTEXT, 262(81-96) (1995)
[Publications] Miyawaki Atsushi,: "Proceedings of the Yamada Conference XXXIX on Calcium as Cell Signal April 26-28,1994 Tokyo,Japan" IGAKU-SHOIN, 263(154-164) (1995)

1995 Fiscal Year Annual Research Report

中枢シナプスの分子生物学

Principal Investigator

三品 昌美 東京大学, 医科部(医), 教授 (80144351)

Research Products

[Publications] Ikeda,K.: "Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel." Mol.Brain Res.33. 61-71 (1995)

[Publications] Mori,H.: "Structure and function of the NMDA receptor channel." Neuropharmacology. 34. 1219-1237 (1995)

[Publications] Morita,T.: "Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain." Neurosci.Lett.198. 131-134 (1995)

[Publications] Kashiwabuchi,N.: "Impairment of motor coordination,Purkinje cell synapse formation and cerebellar long-term depression in GluRδ2 mutant mice." Cell. 81. 245-252 (1995)

[Publications] Sakimura,K.: "Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit." Nature. 373. 151-155 (1995)

[Publications] Kawamoto,S.: "N-linked glycosylation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA)-selective glutamate receptor channel α2 subunit is essential for the acquisition of ligand-binding activity." J.Neurochem.64. 1258-1266 (1995)

[Publications] Watanabe,S.: "Stable production of mutant mice from double gene converted ES cells with puromycin and neomycin." Biochem.Biophys.Res.Commun.213. 130-137 (1995)

[Publications] Hirano,T.: "Suppression of LTD in cultured purkinje cells deficient in the glutamate receptor δ2 subunit." NeuroReport. 6. 524-526 (1995)

[Publications] Yamakura,T.: "Different effects of propofol on various AMPA-,kainate-and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes." Neurosci.Lett.188. 187-190 (1995)

[Publications] Watanabe,M.: "Cerebellum of adult reeler mutant mouse contains two Purkinje cell populations with respect to gene expression for the N-methyl-D-aspartate receptor channel." Neurosci,Res.22. 335-345 (1995)

[Publications] Takayama,C.: "Light-and electron-microscopic localization of the glutamate receptor channel δ2 subunit in the mouse Purkinje cell." Neurosci,Lett.188. 89-92 (1995)

[Publications] Kawamoto,S.: "Expression and characterization of the ζ1 subunit of the N-methyl-D-aspartate(NMDA)receptor channel in a Baculovirus system." Mol.Brain Res.30. 137-148 (1995)

[Publications] Watanabe,T.: "Prostaglandin F2a stimulates formation of the p21ras-GPT complex and mitogen-activated protein kinase activity in NIH-3T3 cells via a Gq-protein-coupled pathway,..." J.Biol.Chem.270. 8894-8990 (1995)

[Publications] Honda,Z.: "Gq Pathway desensitizes chemotactic receptor-induced calcium signaling viainositol trisphosphate receptor dowm-regulation." J.Biol.Chem.270. 4840-4844 (1995)

[Publications] M.Nakamura: "Identification of two isoforms of mouse neuropeptide Y-Y1receptor generated by alternative splicing.Isolation,genomic structure,and functional expression of the receptors." J.Biol.Chem.270. 30101-30108 (1995)

[Publications] Mutoh,H.: "Tissue-specific response of the human platelet-activating factor receptor gene to retinoic acid and thyroid hormone is directed by two distinct promoters." Proc.Natl.Acad.Sci.U.S.A.in press.

[Publications] Yokomizo,T.: "CDNA cloning,expression,and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase." J.Biol.Chem.271. 2844-2850 (1996)

[Publications] Mori,M.: "Predominant expression of platelet-activating factor receptor in the rat brain microglia." J.Neurosci.(in press).

[Publications] Bito,H.: "Platelet-activating factor(PAF)receptor in rat brain PAF mobilizes intracellular Ca^<2+>in hippocampal neurons." Neuron. 9. 285-294 (1992)

[Publications] Yokomizo,T.: "Enzymatic inactivation of leukotriene B_4 by a novel enzyme found in the porcine kidney.Purification and properties of leukotriene B_4 12-hydroxy-dehydrogenase." J.Biol.Chem.268. 18128-18135 (1993)

[Publications] Honda,Z.: "Transfected platelet-activating factor receptor activates mitogen-activated protein(MAP)kinase and MAP kinase kinase in Chinese hamster ovary cells." J.Biol.Chem.269. 2307-2315 (1994)

[Publications] Bito,H.: "Functional coupling of a rat hippocampal somatostatin receptor to inhibition of adentylate cyctase,activation of arachidonate release and mitogen-activated(MAP)kinase." J.Biol.Chem.269. 12727-12730 (1994)

[Publications] Takano,T.: "Role of cytoplasmic-tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization." J.Biol.Chem.269. 22453-22458 (1994)

[Publications] Ferby,I.: "Wormannin inhibits mitogen-activated protein kinase・induced by platelet-activating factor in guinea-pig neutrophils." J.Biol.Chem.269. 30485-30488 (1994)

[Publications] Kim,C.S.: "Alzhcimcr and β-amyloid-treated fibroblasts demonstratc a dccrease in a memory associated GTP-binding protcin,Cp20" Proc.Natl.Acad.Sci.USA. 92. (1995)

[Publications] Inoue,H.: "A novel function for nucleoside diphosphate kinase in Drosophila" Biochem.Biophys.Res.Comm.(in press). 3060-3064

[Publications] Olds,J.L.: "Imaging protcin kinase Cactivation in living sea urchin eggs after fertilization." Develop.Biol.(in press).

[Publications] Hirata,K.: "Baclofen inhibits GABAergic transmission after treatment with type-specific calcium channel blockers in cultured rat hippocampal neurons." Neurosci.Lett.187. 208-208 (1995)

[Publications] Kamiya,H.: "Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fiber synapse." J.Physiol.(in press).

[Publications] Sekiyama,N.: "Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes" British Journal of Pharmacology. (in press).

[Publications] Otsu,Y.: "Hebbin induction of LTP in visual cortex:A perfotated patch clamp syudy in cultured neurons." J.Neurophysiol.74. 2437-2444 (1995)

[Publications] Sato,H.: "Machanisms underlying direction sdectivity of neurons in the primary visual cortex of the macaque." J.Neurophysiol.74. 1382-1394 (1995)

[Publications] Torii,N.: "An inhibitor for calcineurin,FK506 blocks induction of long-term depression in rat visual cortex." Neurosci.Lett.185. 1-4 (1995)

[Publications] Sato,H.: "Broad-tuned chromatic inputs to color-selective neurons in the monkey visual cortex." J.Neurophysiol.72. 163-168 (1994)

[Publications] Funauchi,M.: "Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase.calcineurin,on induction of long-term potentiation in rat visual cortex." Neurosci.Res.19. 269-278 (19954)

[Publications] Yoshimura,Y.: "Deopendence of LTP induction on postsynaptic depolarization:A perforated patch clamp study in visual cortical slices of young rats." J.Neurophysiol.71. 1638-1645 (1994)

[Publications] Ayako Ajima: "A unique role of protein phosphatases in cerebellar long-term depression" Neuro Report. 6. 297-300 (1995)

[Publications] Kazutoshi Nakazawa: "Transient and persistent phosphorylation of AMPA-Type Glutamate Receptor Subunits in Cerebellar Purkinje Cells" Neuron. 15. 697-709 (1995)

[Publications] K.Nakazawa: "Antibody specific for phosphorylated AMPA-Type glutamate receptors at Glur2 Ser-696" Neuroscience Research. 24. 75-86 (1995)

[Publications] Nagai,Y.: "The birth of glycobiology and glycotechnology;Studies of the third chain chain of Life" RIKEN Review. 8. 1-2 (1995)

[Publications] Ohashi,Y.: "Adventures in glyco-mass-stectrometry.Seeking for a better method." RIKEN Review. 8. 45-46 (1995)

[Publications] Nagai,Y.: "Functional roles of gangliosides in bio-signaling." Behavioural Brain Res.66. 99-104 (1995)

[Publications] Ii,T.: "Structural elucidation of underivatized gangliosides by electrospray-ionization tandem mass spectrometry(ESIMS/MS)" Carbohydrate Res.273. 27-40 (1995)

[Publications] Ii,T.: "Fast atom bombardment and electrospray ionization tandem mass spectrometry of sulfated lewis" J.Biochem.118. 526-533 (1995)

[Publications] Nakanishi,S.: "Second-order neurons and receptor mechanisms in visual and olfactory information processing" Trends in Neurosciences. 18. 359-364 (1995)

[Publications] Masu,M.: "Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene" Cell. 80. 757-765 (1995)

[Publications] Kabe,H.: "Synaptic mechanisms of oifactory recognition memory" Reviews in the Neurosciences. 6. 125-141 (1995)

[Publications] Yokoi,M: "Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb" Proceedings of the National Academey of Sciences of the United Statesof America. 92. 3371-3375 (1995)

[Publications] Tokita,Y.: "Characterization of excitatory amino acid neurotoxicity in N-methy1-D-aspartate receptor-deficient mouse cortical neuronal cells" European Journal of Neuroscience. (in press).

[Publications] Moriyoshi,K.: "Labeling living neurons by adenovirus-mediated gene transfer of modified membrane-targeted green fluorescent protein" Neuron. (in press).

[Publications] M.Kasai: "Effects of KC1 concentrations on gating properties of calcium release channels in sarcoplasmic reticulum vesicles." J.Biochem.117. 251-256 (1995)

[Publications] T.Ide: "An anion channel from transverse tubular membranes incorporated into planar bilayers." Biochim.Biophys.Acta.1237. 115-120 (1995)

[Publications] N.Yamaguchi: "DIDS binding 30-kDa protein regulates the calcium release channel in the sarcoplasmic reticulum." Biochem.Biophys.Res.Commun.210. 648-653 (1995)

[Publications] M.Ohkura: "Calsequestrin is essential for the Ca^<2+> release induced by miotoxin α in skeletal muscle sarcoplasmic reticulum." Can.J.Physiol.Pharmacol.73. 1181-1185 (1995)

[Publications] S.B.Sato: "Enhancement of fluid-phase endocytosis by high-calcium medium and factors" Cell Physiology. (in press).

[Publications] Hirota,J.: "Kinetics of calcium release by immunoaffinity-purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles." J.Biol.Chem.270(32). 19046-19051 (1995)

[Publications] Ogawa,M.: "The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons." Neuron. 14. 899-912 (1995)

[Publications] Fukuda,M.: "Functional diversity of C2 domains of synaptotagmin family." J.Biol.Chem.270(44). 26523-26527 (1995)

[Publications] Fukuda,M.: "Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10708-10712 (1995)

[Publications] Mikoshiba,K.: "Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10703-10707 (1995)

[Publications] Monkawa,T.: "Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits." J.Biol.Chem.270. 14700-14704 (1995)

[Publications] Matsumoto,M.: "Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor." Nature. 379. 168-171 (1996)

[Publications] Aruga,J.: "The mouse zic gene family(Homologues of the Drosophila pair-rule gene odd paired." J.Biol.Chem.271. 1043-1047 (1996)

[Publications] S.Mochida: "Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not ca ^<2+> channel activity." Neuroscience. 65. 905-915 (1995)

[Publications] K.Ibaraki: "Identification of four different forms of syntaxin 3" Biochem.Biophys.Res.Commun.221. 997-1005 (1995)

[Publications] H.Tokumaru: "A calcium channel from the presynaptic nerve terminal of the Narke japonica electric organ contains a non-N-type α_2δ subunit." J.Neurochemistry. 651. 831-836 (1995)

[Publications] T.Ishizuka: "Synaphin:a protein associated with the docking/fusion complex in presynaptic terminals." Biochem.Biophys.Res.Commun.213. 1107-1114 (1995)

[Publications] 吉岡 亮: "情報生物学シリーズ4「シナプス伝達のダイナミクス」" 培風館, 146 (1995)

[Publications] Yagai,Y.: "″Cellular Biology of Gangliosides″in Biology of the Slalic Acids(eds.by Rosenberg,A.)" Plenum Press,New York, 197-241 (1995)

[Publications] Hirota Junji,: "Genes for development,cell growth and infectious diseases(A decade of Pasteur Riken collaboration)" John Libbey EUROTEXT, 262(81-96) (1995)

[Publications] Miyawaki Atsushi,: "Proceedings of the Yamada Conference XXXIX on Calcium as Cell Signal April 26-28,1994 Tokyo,Japan" IGAKU-SHOIN, 263(154-164) (1995)

三品昌美東京大学, 医科部(医), 教授 (80144351)

[Publications] 吉岡亮: "情報生物学シリーズ4「シナプス伝達のダイナミクス」" 培風館, 146 (1995)