1994 Fiscal Year Final Research Report Summary
Placental function and development of fetal nervous system.
| Project/Area Number |
04304024
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎獣医学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OGAWA Tomoya Univ of Tokyo, Fac.Agri., Professor, 農学部, 教授 (30087572)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Haruto Miyazaki Univ.Fac.Agri., Associate Prof., 農学部, 助教授 (40040852)
NISHIHARA Masugi Univ of Tokyo, Fac.Agri., Associate Prof., 農学部, 助教授 (90145673)
MORI Yuji Univ of Tokyo, Fac.Agri., Associate Prof., 農学部, 助教授 (40157871)
HAYASHI Yoshihiro Univ of Tokyo, Fac.Agri., Professor, 農学部, 教授 (90092303)
SHIOTA Kunio Univ of Tokyo, Fac.Agri., Associate Prof., 農学部, 助教授 (80196352)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Placental Lactogen / Fetal Brain / Placenta / 20alpha-Hydroxysteroid Dehydrogenase / Recombinant Protein / Prolactin / Prolactin Receptor / Maternal Behavior |
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| Research Abstract |
The placenta plays an essential role in fetal growth and survival, maintenance of the maternal metabolic status during pregnancy by virtue of its multiple functions relating to the transport of nutrients and waste between mother and fetus, modulation of the maternal and fetal immune systems to prevent rejection of each other, and its endocrinological function of maintaining the pregnancy. The main endocrine participation of the placenta is attributed to placental lactogens(PLs). Considering the phenomenon that twice daily surges of prolactin ceased when secretion of PLs started in the rat and administration of prolactin, which is structurally related to the PLs, stimulates maternal behavior the animals, the PLs are proposed to affect the central nervous function in the dam. In the present study, we showed that the mRNA for PL or prolactin receptor expressed in the fetal rat brain during fetal development. We also succeeded to isolate cDNAclone for a novel PL,PL-Im, and produce the recombinant protein. In the course of these studies, monoclonal antibodies which recognize the molecule in the developing fetal brain were obtained. mRNA for 20alpha-hydroxysteroid dehydrogenase expressed in the placenta to protect the fetus from the maternal steroid environment.
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