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1994 Fiscal Year Final Research Report Summary

Recent change of Risk factors of Ischemic Cordio-and Cerebrovasular Diseases

Research Project

Project/Area Number 04304036
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMAMOTO Takashi  University of Tsukuba, Institute of Community Medicene, Professor, 社会医学系, 教授 (50143178)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yoji  Yamanashi Medical College Department of Pathology, Professor, 病理学, 教授 (10008237)
KODAMA Kazunori  Radiation Effects Research Foundation.Department of Clinical Studies, Director, 臨床研究部, 部長 (70161940)
UEDA Kazuo  Kyushu University Medical School, Professor, 医療技術短期大学部, 教授 (10038812)
IIDA Minoru  Center for Adult Deseases, Osaka, Dept of Epidemiology and Mass Examination, Dir, 集検1部, 部長
KOMATI Yoshio  Osaka Prefectual Institute, President, 所長 (50134242)
Project Period (FY) 1992 – 1994
KeywordsLacunar infarction / Thrombeembolic infarction / Risk factors / Cohort study / Serum fatty acids / Plasma fibrinogen / Tissue plasminogen / Asymptomatic infarction
Research Abstract

The data from a long-term epidemiologic studies in populations in ibaraki, Akita, Osaka, Kochi, Hiroshima, Nagasaki, Fukuoka was analyzed and the following results were obtained.
1) The proportion of cerebral infarction among total stroke increased in each population. According to computer tomography (CT) findings, the proportion was highest in lacunar infarction, and progressively lower in embolic infarction and in thrombotic infarction. The proportion of lacunar infarction was higher in Japanese populations than in Western populations. Incidence of ischemic heart disease has increased in urban male employees, but has not changed in other populations.
2) A cohort of 25,811 men and women aged 40-69 was followed 9 to 10 years and 779 stroke and 307 ischemic heart disease incidence cases were obtained. Significant risk factors shown by regression analyzes were hypertension for lacunar infarction, high serum total cholesterol, alcohol intake, left ventricular hypertrophy for thrombotic infa … More rction, and atrial infarction and left ventricular hypertrophy for embolic infarction. Risk factors for ischemic heart disease were high serum total cholesterol, high blood pressure, and cigarette smoking.
3) According to a prospective nested case-control study in rural populations, the proportion of serum polyunsaturated fat, in particular n-6 fatty acids was lower in stroke incidence cases, either hemorrhagic or non-hemorrhagic stroke than in controls.
In urban populations, the proportion of n-3 fatty acids tended to be lower in ischemic heart disease cases than in controls. Plasma fibrinogen concentrations were higher in patients of ischemic heart disease than in control.
4) Related factors for serum fatty acids, plasma fibrinogen and tissue plasminogen activator inhibitor I included cigarette smoking, alcohol intake and fish intake.
Pathologic study showed that a probable cause of vascular dementia was nonsymptomatic lacunar infartion in basal ganglia which was acceralated by aging and hypertension. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 山海知子,嶋本喬,小町喜男他: "CT所見を中心とした脳卒中の疫学的研究-コホート内症例対照研究による脳出血、脳梗塞の病型別発生要因の検討" 日本公衆衛生雑誌. 39. 410-420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤真一,飯田稔,小町喜男他: "脂肪酸構成からみた栄養摂取と循環器疾患の関連に関する研究-虚血性心疾患の集団内症例対照研究" 公衆衛生. 57. 871-875 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 磯博康,嶋本喬,小町喜男他: "Plasma Fibrinogen and its Correlntes in Japanese and US Population Samples" Arteriosclerosis and Thrombosis. 70. 475-480 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上田一雄: "循環器疾患の危険因子、本邦における特徴とその変遷" 日本循環器管理研究協議会雑誌. 29. 57-67 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 児玉和紀: "Stroke Trends in Japan" Ann.Epidemiol.3. 524-528 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉田洋二他: "脳卒中病態の変遷に関する基礎的研究" 臨床成人病. 24. 1418-1423 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上田一雄: "日本人における高血圧の予後と将来展望" メディカルトリビューン, 202 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sankai T,Shimamoto T,Komati Y,et al.: "A Nested Case-control Study of Risk Factors for Intracerebral Hemorrhage and Cerebral Infaction Classified by Computed Tomographic Findings." Jpn J Public Health. 39. 410-420 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato S,Iida M,Komati Y,et al: "The relation of serumfatly acid composition with diet and Cardiovascular disease, a nested casecontrol study on coronary heart diseases." Public Health. 57. 871-875 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iso H,Shimamoto T,Komati Y,et al: "Plasma Fibrinogen and its correlates in Japanese and US Population Samples" Arteriosclerosis and Thrombosis. 70. 475-480 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda K.: "Risk (TD) factor for Cardiorascular Desease characteristics and trends in Japan." J Jpn Assoc Cerebro-cardiorascular Dis. 29. 57-67 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kodama K.: "Stroke Trends in Japan" Ann.Epidemiol. 3. 524-528 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida Y.et al.: "Fundmental study on changes in pathogenesis of stroke." Ryinsho Seijinbyo. 24. 1418-1423 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda K.: "Probnosis and perspectives of hypertension in Japan" Medical Tribune. (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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