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1993 Fiscal Year Final Research Report Summary

Development of clinical liver transplantation

Research Project

Project/Area Number 04304041
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

TAKAGI Hiroshi  Nagoya Univ.School of Med.Professor, 医学部, 教授 (70154755)

Co-Investigator(Kenkyū-buntansha) TANIKAWA K.  Kurume Univ.School of Med.Professor, 医学部, 教授 (10080649)
DOI K.  Hiroshiam Univ.School of Med.Professor, 医学部, 教授 (90034024)
ORITA K.  Okayama Univ.Med.School Professor, 医学部, 教授 (20033053)
MORI T.  Osaka Univ.Med.School Professor, 医学部, 教授 (60028496)
OHTA K.  Tokyo Women's Medical College Professor, 教授 (40090659)
Project Period (FY) 1992 – 1993
Keywordsliver transplantation / cold preservation / ischemic live injury / ischemic reperfusion injury / xenotransplantation / end stage liver disease / 拒絶反応 / 末期肝不全
Research Abstract

The aim of this research is to establish a foundamental basis for the development of clinical liver transplantation. Subjects involved in this research include both experimental and clinical investigations. They consist of the following four main items :
1. Organ procurement and preservation ;
2. Surgical techniques of liver transplantation and post operative management based on clinical experiences in living-related partial liver transplantation and cadaveric liver transplantation from the non-heart beeting donors ;
3. Transplantation immunology, immunosuppression therapy and induction of immunological tolerance ;
4. Indications for liver transplantation in patients with end stage liver disease and development of procurement network in Japan.
The results and knowledge obtained from this research project are valuable and important for the development of cadaveric liver transplantation from brain dead donors in Japan.

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Sumimoto,R.et al: "A Comparison of Histidine-Lactobionate and UW Solution 48-hour Dog Liver Preservation." Transplantation. 54(4). 610-614 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Goto,M.et al: "Tumor Necrosis Factor and Endotoxin in the Pathogenesis of Liver and Pulmonary Injuries after Orthotopic Liver Transplantation in the Rat." Hepatology. 16(2). 487-493 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Omura,T.et al: "Accelerated Rejection of Allografted Rat Liver Perfused with Anti-ICAM-1 Monoclonal Antibody." Immunobiology. 186. 241-245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 横山逸男、高木弘: "肝移植の現状" 医学のあゆみ. 164(6). 482-486 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato,E.et al: "Protective Effects of Carolina Rinse Solution against Reperfusion Injury in Canine Renal Autotransplantation." European Surgical Research. 25. 254-260 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Negita,M.et al: "Relationship Between Superoxide Dismutase Activity of Liver Tissue and Survival in Swine Liver Transplantation." Transplantation Proceedings. 25(6). 3213-3214 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaoka,Y.et al: "Arterial Ketone Body Ratio as a Predictor of Donor Liver Viability in Human Liver Transplantation." Transplantation. 55(1). 92-95 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakano,Y.et al: "Permanent Acceptance of Liver Allografts by Intraportal Injection of Donor Spleen Cells in Rats." Surgery. 111(6). 668-676 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanikawa,K.: "Indication of Liver Transplantation for Hepatocellular Carcinoma in Japan." Surgery Today. 22. 395-400 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koyamada,N.et al: "Induction of Specific Tolerance by Hepatic Double-Negative CD4^-8^-αβ T Cells of Mice Immunized with Allogeneic Cells Via the Portal Vein in Vitro." Cellular Immunology. 149. 107-116 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 太田和夫: "わが国における臓器移植の現状と課題" 外科治療. 70(1). 25-29 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.Sumimoto, S.L.Lindell, J.H.Southard, et al: "A Comparison of Histidine-Lactobionate and UW Solution in 48-hour Dog Liver Preservation." Transplantaion. Vol.54 No.4. 610-614 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Goto, Y.Takei, S.Kawano, et al: "Tumor Necrosis Factor and Endotoxin in the Pathogenesis of Liver and Pulmonary Injuries after Orthotopic Liver Transplantation in the Rat." Hepatology. Vol.16 No.2. 487-493 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Omura, H,Ishikura, Y.Nakajima, et al: "Accelerated Rejection of Allografted Rat Liver Perfused with Anti-ICAM-1 Monoclonal Antibody." Immunobiology. Vol.186. 241-245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Yokoyama, H.Takagi: "Liver Transplantation : Present Status." Igaku no Ayumi. Vol.164 No.6. 482-486 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, T.Hachisuka, I.Yokoyama, et al: "Protective Effects of Carolina Rinse Solution against Reperfusion Injury in Canine Renal Autotransplantation." European Surgical Research. Vol.25. 254-260 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Negita, I.Yokoyama, H.Kobayashi, et al: "Relationship Between Superoxide Dismutase Activity of Liver Tissue and Survival in Swine Liver Transplantation." Transplantation Proceedings. Vol.25 No.6. 3213-3214 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamaoka, M.Washida, D.Manaka, et al: "Arterial Ketone Body Ratio as a Predictor of Donor Liver Viability in Human Liver Transplantation." Transplantation. Vol.55 No.1. 92-95 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Nakano, M.Monden, L.A.Valdivia, et al: "Permanent Acceptance of Liver Allografts by Intraportal Injection of Donor Spleen Cells in Rats." Sugery. Vol.111 No.6. 668-676 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanikawa: "Indication of Liver Transplantation for Hepatocellular Carcinoma in Japan." Surgery Today. Vol.22. 395-400 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Koyamada, T.Ohteki, T.Abo, et al: "Induction of Specific Tolerance by Hepatic Double-Negative CD4^-8^- alpha beta T Cells of Mice Immunized with Allogeneic Cells Via the Portal Vein in Vitro." Cellular Immunology. Vol.149. 107-116 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Ohta: "Current Status of Organ Transplantation in Japan." Geka-Chiryo. Vol.70 No.1. 25-29 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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