1994 Fiscal Year Final Research Report Summary
A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS
| Project/Area Number |
04304052
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | TOHOKU UNIVERSITY (1994)
Hokkaido University (1992-1993) |
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Principal Investigator |
KASAI Noriyuki TOHOKU UNIVERSITY SCHOOL OF MEDCINE,PROFESSOR, 医学部, 教授 (60001947)
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| Co-Investigator(Kenkyū-buntansha) |
KAMATAKI Tetsuya FACULTY OF PHARMACOLOGY HOKKAIDO UNIVERSITY,PROFESSOR, 薬学部, 教授 (00009177)
SUGIYAMA Yuichi FACULTY OF PHARMACOLOGY UNIVERSITY OF TOKYO,PROFESSOR, 薬学部, 教授 (80090471)
ANDO Susumu TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY,THE HEAD OF A DIVISION, 部長 (30073000)
YOSHIDA Michihiro HOKKAIDO UNIVERSITY FACULTY OF SCIENCE,PROFESSOR, 理学部, 教授 (60001765)
MORIWAKI Kazuro FUKUYAMA UNIVERSITY FACULTY OF TECHNOLOGY,PROFESSOR, 工学部, 教授 (50000229)
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| Project Period (FY) |
1992 – 1994
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| Keywords | EXTRAPOLATION / SPECIES DIFFERENCES / GENE / PHARMACOKINETICS / GENETIC HOMOLOGY / LABORAATORY ANIMALS / STRAIN DIFFERENCES / ANIMAL SCALE UP |
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| Research Abstract |
EXTRAPOLATION MEANS TO PRESUME THE RESULTS ON HUMAN BEINGS FROM THE RESULTS OF EXPERIMENTATION USING LABORATORY ANIMALS.HOWEVER,AN ACCURATE EXTRAPOLATION IS PREVENTED BY THE SPECIES DIFFERENCES BETWEEN HUMAN BEINGS AND ANIMALS.WE INVESTIGATED THE WAY OF EXTRAPOLATION BY THE COMPARISON OF THE PHARMACOKINETICS AND THE GENETIC ANALYSIS BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS.
THIS RESEARCH LASTED FOR THREE YEARS,AND WE DEVELOPED NEW FIELD FOR LABORATORY ANIMAL SCIENCE.BUT MORE RESEARCH IS NEEDED FOR ESTABLISHMENT OF THE NEW METHODS OF EXTRAPOLATION.WE HELD A SYMPOSIUM ON THE EXTRAPOLATION AT TOKYO,AND ABOUT 250 RESEARCERS PARTICIPATED IN THIS SYMPOSIUM.I THINK THIS IS FIRST SYMPOSIUMON THE EXTRAPOLATION IN JAPAN.
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