1993 Fiscal Year Final Research Report Summary
Genetic basis of spontaneous activity and its modifying process in mice
| Project/Area Number |
04451017
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MAKINO Junshiro University of Tsukuba, Institute of Psychology professor, 心理学系, 教授 (60015443)
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| Project Period (FY) |
1992 – 1993
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| Keywords | behavior genetics / inbred strains of mice / open-field behavior / avoidance leaning |
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| Research Abstract |
The prupose of the study was to determine the hereditary mode of open-field behavior by crossing method in two inbred strains of mice ; BALB/c and C57BL/6, and to determine the effect of the strain characteristic responsiveness to shock on shuttle avoidance learning.
In experiment 1, open field behavior of BALB, C57BL, two types of F1 and F2 were directly observed for 10 min by multiple-even time sampling method with 9 behavioral items. As a sequential anaysis, BALB/c showed frequent sequences between stretching and sniffing or locomotion during the first 5 min. On the other hand, C57BL showed frequent sequences between locomotion and rearing or leaning without the sequences of stretching mentioned above in BALB.F1 showed a mixed sequences. They locomoted as much as C57BL, but showed many stretchings in addition to it. Further analysis is needed about F2.
In experiment 2 and 3, (1)the way mice respond to shock was observed by 7 items in 4 inbred strains of mice. C3H increased jumping to shock stronger than 2mA, but other strains(BALB, C57BL and DBA) showed no this tendency. They increased running as shock intensity became higher. (2)Then suttle avoidance was trained using 3 different intensities of shock in the same 4 strains. As shock became stronger, C3H showed jumping or rearing type of avoidance much more than the other 3 strains. It may be concluded that the dominat response type to shock would make an important role on shock avoidance leaning.
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