1994 Fiscal Year Final Research Report Summary
Antitumor Precious Metal Complexes and their Interaction with Biollogically Related Moleale
| Project/Area Number |
04453043
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
無機・錯塩・放射化学
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| Research Institution | Kitasato University (1994)
The University of Tokyo (1992-1993) |
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Principal Investigator |
MIYAMOTO Takeshi Kitasato Univ.School of Sci.Professor, 理学部, 教授 (30011604)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Platinum Complexes / Water-Solubll Complexes / Phosphane / Arsane / Stibane / Hydroxy Complexes |
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| Research Abstract |
The aqueous chemistry of platinum (II) complexes with phosphorus, arsenic and antimonious donors are still scanty and undeveloped whereas that of the am (m) ine complexes are well known as exemplified in spasmodic reports of cisplatin. A series of new water soluble platinum (II) complexes stabilized with trimenthylphosphane, trimethylarsane or trimethylstibane were synthesized for the first time by the elegant use of the anion-exchange resin. Their cystal structures were determined by X-ray diffration method. The solution equilibria among these complexes were investigated by ^1H.^<13>C,^<31>P or ^<195>pt NMR spectrscopy. Acid base equilibria among cis- [Pt (OH) _2 (AMe_3) _2], cis- [Pt (OH) (AMe_3) _2]_2^<2+> and cis- [Pt (OH_2) _2 (AMe_3) _2]^<2+> (where A=PMe_3, AsMe_3 or SbMe_3) were well established.
Dihydroxide complex, cis- [Pt (OH) _2 (AMe_3) _2]・nH_2O affords several water soluble complexes in a quantitative yield by the simple reaction with free acid, e.g., oxalic acid or CO_2. This demonstrates that new hydroxides are potentially good material for the preparation of many water-soluble complexes. In near future, the interaction between the hydroxide and a biologically related molecule (ascorbic acid or nucleic acid) will be surveyed.
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