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1993 Fiscal Year Final Research Report Summary

Catalyic Asymmetric Synthesis Using Rare Earth Metals

Research Project

Project/Area Number 04453150
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionUniversity of Tokyo

Principal Investigator

SHIBASAKI Masakatsu  University of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30112767)

Co-Investigator(Kenkyū-buntansha) SODEOKA Mikiko  University of Tokyo, Faculty of Pharmaceutical Sciences, Research Associat, 薬学部, 助手 (60192142)
SASAI Hiroaki  University of Tokyo, Faculty of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 (90205831)
Project Period (FY) 1992 – 1993
KeywordsRare Earth Metal / Optically Active Complex / Catalytic Asymmetric Synthesis / Nitroaldol / beta-Blocker
Research Abstract

The structure of the optically active rare earth metal complex 1 has been unequivocally determined. The use of 1 has made possible a catalytic asymmetric synthesis of pindolol.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] H.Sasaki: "Basic Character of Rare Earth Metal Alkoxides Utilization in Catalytic C-C Bond-Forming Reactions and Catalytic Asymmetric Nitroaldol Reactions" J.Am.Chem.Soc.114. 4418-4420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Sasaki: "Catalytic Asymmetric Nitroaldol Reactions:A New Practical Method for the Preparation of Optically Active Lanthanum Complex" Tetrahedron Lett.34. 851-854 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Sasaki: "Catalytic Asymmetric Nitroaldol Reactions:An Efficient Synthesis of(S)Propranolol Using the Lanthanum Binaphthol Complex" Tetrahedron Lett.34. 855-858 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Sasaki: "Effects of Rare Earth Metals on the Catalytic asymmetric Nitroaldol Reaction" Tetrahedron Lett.34. 2657-2660 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Sasaki: "Catalytic Asymmetric Nitroaldol Reaction Using Optically Active Rare Earth BINOL Complexes:Investigation of the Catalyst Structure" J.Am.Chem.Soc.115. 10372-10373 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柴崎正勝: "光学活性希土類錯体を用いる触媒的不斉炭素-炭素結合生成反応" 有機合成化学協会雑誌. 51. 972-984 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Sasai, T.Suzuki, S.Arai, T.Arai, and M.Shibasaki: "Basic Character of Rare Earth Metal Alkoxides. Utilization in Catalytic C-C Bond-Forming Reactions and Catalytic Asymmetric Nitroaldol Reactions" J.Am.Chem.Soc.114. 4418-4420 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasai, T.Suzuki, N.Itoh, and M.Shibasaki: "Catalytic Asymmetric Nitroaldol Reactions : A New Practical Method for the Preparation of the Optically Active Lanthanum Complex" Tetrahedron Lett.34. 851-854 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasai, N.Itoh, T.Suzuki, and M.Shibasaki: "Catalytic Asymmetric Nitroaldol Reactions : An Efficient Synthesis of (S) Propranolol Using the Lanthanum Binaphthol Complex" Tetrahedron Lett.34. 855-858 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasai, T.Suzuki, N.Itoh, S.Arai, and M.Shibasaki: "Effects of Rare Earth Metals on the Catalytic asymmetric Nitroaldol Reaction" Tetrahedron Lett.34. 2657-2660 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasai, T.Suzuki, N.Itoh, K.Tanaka, T.Date, K.Okamura, and M.Shibasaki: "Catalytic Asymmetric Nitroaldol Reaction Using Optically Active Rare Earth BINOL Complexes : Investigation of the Catalyst Structure" J.Am.Chem.Soc.115. 10372-10373 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasai, T.Arai, and M.Shibasaki: "Catalytic Asymmetric C-C Bond-Forming Reaction Using Optically Active Rare Earth Complex" J.Syn.Org.Chem.Jap.51. 972-984 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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