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1993 Fiscal Year Final Research Report Summary

Mechanisms of molecular changes in amino acids due to inner shell ionization

Research Project

Project/Area Number 04453162
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 放射線5生物学
Research InstitutionNational Laboratory for High Energy Physics

Principal Investigator

KOBAYASHI Katsumi  National Institute for High Energy Physics, Photon Factory, Associate Professor, 放射光実験施設, 助教授 (20114077)

Project Period (FY) 1992 – 1993
KeywordsMonochromatic soft X-rays / Amino acids / Synchrotron radiation / Radiolysis / K-shell photoabsorption / Inner shell excitation
Research Abstract

It was reported that the radiobiological effects are enhanced when monochromatic soft X-rays corresponding to the absorption edges of the constituent atoms are irradiated. We have been studying this enhancement mechanism. In this research, we investigated the mechanisms of molecular changes of sulfur-containing amino acids irradiated with monochromatic soft X-rays around sulfur K-shell absorption edge, expecting that this might be a underlying mechanism of the biological enhancement.
Research results are summarized as follows.
a)Covalent bonds including the inner shell ionized atom are cleaved more effectively than the other bonds.
b)Carbon-sulfur bonds are sensitive not only to the photoabsorption of sulfur but also to that of the other constituent atoms.
c)When irradiated in aqueous solution, OH adducts of the fragments are observed.
d)Cleavage efficiency of the sulfur-carbon bond is not affected by the addition of OH radical scavenger, indicating that cleavage of the bond mainly occurs via direct action of the radiation.
Since we could not identify the all fragments observed in the HPLC chart, we are considering new identification methods such as the use of radioisotope tracers.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] H.Yamada: "Effects of the K-shell X-ray absorption of Phosphorus on the Scission of the Pentadeoxythymidylic Acid" International Journal of Radiation Biology. 63. 151-159 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林克己: "放射光を用いたオージェ治療の可能性" 放射線医学物理. 13. 178-185 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Radiation Biology of Inner Shell Ionization/Excitation" SR in Biosciences,Oxford Univ.Press. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yamada et al.: "Effects of the K-shell absorption of phosphorus on the scission of the pentadeoxythymidylic acid." Int.J.Radiat.Biol.Vol.63. 151-159 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kobayashi: "Radiation biology of inner shell ionization/excitation" "Synchrotron Radiation in Biology" Oxford Univ.Press.714-720 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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