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1994 Fiscal Year Final Research Report Summary

Molecular analysis of cell differentiation and morphogenesis by mesoderm inducing factor

Research Project

Project/Area Number 04454029
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 動物発生・生理学
Research InstitutionThe University of Tokyo (1993-1994)
Yokohama City University (1992)

Principal Investigator

ASASHIMA Makoto  The University of Tokyo, College of Arts and Sciences, professor, 教養学部, 教授 (00090564)

Project Period (FY) 1992 – 1994
KeywordsActivin / Follistatin / Mesoderm induction / Xenopus / Vittelogenin / Nneural induction / Pronephros / Hedgehog gene
Research Abstract

There are several lines of evidence that activin is a crucial molecules for mesoderm induction in early Xenopus and newt embryos. Three isoforms of activins A,B and B,were demonstrated to be present at least in part as a complex with abundant follistatin in early Xenopus embryos (stage 1-5). Animal-half blastomeres from the late 8-cell stage Xenopus embryo respond to activin, and there are prepatterns in ventral and dorsal cells from very early stages. Histological differentiation of the pronephric tubules on the presumptive ectoderm were induced by the mixture of activin A and retinoic acid. The induced pronephric tubules showed exactly the same expression stage and pattem for both marker genes, Xlim 1 and Xlcaax-1, as compares to that of normal embryos. Activin and follistatin protein were found to be localized uniformly in yolk platelets. Some kind of genes, sonic hedgehog, HMG and GS genes, are cloned related with neural formation.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Fukui,A.et al.: "Identification of activins A,AB,and B and follistatin proteins in the Xenopus embryos." Develop.Biol. 163. 279-281 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Uchiyama et al.: "Localization of activin and follistatin proteins in the Xenopus Oocyte" Biochem.Biophys.Res.Commun.202. 484-489 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Fukui et al.: "Control of cell differentiation and morphogenesis in amphibian development" Int.J.Develop.Biol. 38. 257-266 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kinoshita et al.: "HMG-X,a Xenopus gene encoding an HMG1 homolog,is a abundantly expressed in the developing nervous system" FEBS Letter. 352. 191-196 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asashima,M: "Mesoderm Induction during Early Amphibian Development" Develop.Growth & Differ. 36(4). 343-355 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ariizimi T.et al.: "In vitro control of the embryonic from of Xenopus laevis by activin A Time and dose-dependent inducing properties of activin-treated ectodem." Develop.Growth & Differ. 36(5). 499-507 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinoshita,K.et al.: "Growth Factors:Cell Growth,Morphogenesis,and Transformation" Japanese Scientific Societies Press, 178 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 浅島 誠: "卵から親へ 生命体の発生" クバプロ出版会, 172 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukui, A.et al.: "Identification of activins A,AB,and B and follistatin proteins in the Xenopus embryos." Develop.Biol.163. 279-281 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Uchiyama et al.: "Localization of activin and follistatin proteins in the Xenopus Oocyte" Biochem.Biophys.Res.Commun.202. 484-489 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Fukui et al.: "Control of cell differentiation and morphogenesis in amphibian development" Int.J.Develop.Biol.38. 257-266 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Kinoshita et al.: "HMG-X,a Xenopus gene encoding an HMG1 homolog, is abundantly expressed in the developing nervous system" FEBS Letter. 352. 191-196 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M: "Mesoderm Induction during Early Amphibian Development" Develop.Growth & Differ. 36 (4). 343-355 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arizimi T.et al.: "In vitro control of the embryonic form of Xenopus laevis by activin A : Time and dose-dependent inducing properties of activin-treated ectoderm." Develop.Growth & Differ.36 (5). 499-507 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinoshita, K.et al.: Growth Factors : Cell Growth, Morphogenesis, and Transformation. Japanese Scientific Societies Press, 178 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asashima, M.: Development of the Life, from Egg to Adult. Kubapuro, 172 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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