1994 Fiscal Year Final Research Report Summary
VIRUS-HOST INTERACTIONS IN A NON-THYMIC LYMPHOMA MOUSE MODEL
| Project/Area Number |
04454187
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
HIAI Hisoshi KYOTO UNIVERSITY,FACULTY OF MEDICINE PROFESSOR, 医学部, 教授 (10073131)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yoshihiro FACULTY OF MEDICINE ASSIST.PROF., 医学部, 助手 (30252464)
ISHIMOTO Akinori INSTITUTE FOR VIRUS RESEARCH PROFESSOR, ウイルス研究所, 教授 (50073127)
TOYOKUNI Shinya FACULTY OF MEDICINE LECTURER, 医学部, 講師 (90252460)
FUKUMITO Manabu FACULTY OF MEDICINE ASSOC.PROF., 医学部, 助教授 (60156809)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Lymphoma / Genetic susceptibility / Genetic analysis / Endogenous retrovirus / T-lymphoma / Pre-B lymphoma / Host factor / Microsatellite |
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| Research Abstract |
Lymphomagenesis in mice is dependent on endogenous retrovirus. It is, however, a multi-step phenomenon involving numerous host factors, thus assumed to be a model of multifactorial genetic diseases. We have studied genetic basis of the pre-B lymphomas in SL/Kh strain mice. In crosses with NFS/N strain, lacking endogenous ecotropic virus and spontaneous lymphomas, all lymphomas developed only when Emv-11 provirus was expressed. In the backcross mice to NFS/N,pre-B lymphomas developed only in the mice with SL/Kh-derived MHC allele, and follicular center cell lymphomas occured only in the homezygotes for NFS-derived allele both at MHC and foc-1 locus on Chr.4. We further examined the cross between SL/Kh and AKR/Ms strain. T-lymphoma-prone mice. In the backcross to AKR,development of T-lymphomas was determined by a single dominant gene Tlsm-1 (T-lymphoma susceptible mouse-1) and Tlsm-1 was mapped at map position 62 cM on Chr.7. Similar gene was identified in AKXD RI strains as wellas in chemical-induced T-lymphomas in F344 rats in the homologous region of Chr.7. These findings clearly indicate that the types of lymphomas are determined by a combination of host genes and may suggest that this hypothesis could be extended to human lymphomas.
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[Publications] Yanagawa, S., Kakimi, K., Tanaka, H., Murakami, A., Nakagawa, Y., Kubo, Y., Yamada, Y., Hiai, H., Kuribayashi, K., Masuda, T., Ishimoto, A.: "Mose mammary tumor virus with rearranged long terminal repeats causes murine lymphomas." J.Virol. 67. 112-118 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] Shimada, M.O., Yamada, Y., Nakakuki, Y., Okamoto, K., Fukumoto, M., Honjo, T., Hiai, H.: "SL/Kh strain mice : a novel model of pre-B lymphomas." Leuk.Res.17. 573-578 (1993)
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[Publications] Hiai, H., Yamada, Y., Shimada, M.O., Okamoto, K., Matsushiro, H., Toyokuni, S.: "A lymphoma model by retrovirus. (in Japanese)" Saishin Igaku. 48. 1525-1530 (1993)
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[Publications] Okamoto, K., Yamada, Y., Ogawa, M.S., Toyokuni, S., Nakakuki, Y., Ikeda, H., Yoshida, O., Hiai, H.: "Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice." Cancer Res.54. 399-402 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Yamada, Y., Matsushiro, H., Ogawa, M.S., Okamoto, K., Nakakuki, Y., Toyokuni, S., Fukumoto, M., Hiai, H.: "Genetic predisposition to pre-B lymphomas in SL/Kh strain mice." Cancer Res.54. 403-407 (1994)
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[Publications] Yamada, Y., Shisa, H., Matsushiro, H., Kamoto, T., Kobayashi, Y., Kawarai, A., Hiai, H.: "T-lymphomagenesis is determined by a dominant host gene Thymic Lymphoma Susceptible Mouse-1 (TLSM-1) in mouse models" J.Exp.Med.180. 2155-2162 (1994)
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