1994 Fiscal Year Final Research Report Summary
RESEARCHES ON IMPROVEMENT OF PERTUSSIS VACCINE
| Project/Area Number |
04454281
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | TOKAI UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
SAKAI Harumi Tokai Univeirsity School of Medicine, 医学部, 助教授 (00102830)
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| Co-Investigator(Kenkyū-buntansha) |
KIM Ryuichi Tokai Univeirsity School of Medicine, 医学部, 助手 (70256113)
OH Yasumasa Tokai Univeirsity School of Medicine, 医学部, 助手 (40246111)
HAYASHI Hideki Tokai Univeirsity School of Medicine, 医学部, 助手 (30189659)
MITSUDA Rumi Tokai Univeirsity School of Medicine, 医学部, 助手 (60209806)
OHTA Kazuyo Tokai Univeirsity School of Medicine, 医学部, 助手 (00214122)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Acellular Pertussis Vaccine / DTP / ELISA / Efficacy of pertussis vaccine / 酵素抗体法 / Enzyme-linked lmmunosorbent Assay-ELISA |
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| Research Abstract |
In Japan DTP vaccine containing acellular pertussis vaccine totally replaced DTP which contained whole cell pertussis vaccine. Since then acceptance rates of third doses of pertussis vaccine remained over 80%. Pertussis has steadily decreased in Japan. The purpose of this study was to evaluate current acellular pertussis vaccine in Japan. Antibody responses to acellular vaccines were evaluated by the most sensitive ELISA.Secondary attack rates were evaluated. National survey of the pertussis patients was performed by a research team.
It was concluded that children given three doses of acellular pertussis vaccine showed antibody responses comparable to those who contracted natural pertussis infection. Studies on secondary attack rates by family contact study revealed the acellular pertussis vaccine was very effective.
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