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1994 Fiscal Year Final Research Report Summary

Persistence and Neuromechanisms of Acquired Seizure Susceptibility Induced by Afterdischarge Repetition.

Research Project

Project/Area Number 04454301
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SATO Mitsumoto  Tohoku Univ.Sch.Med. Professor, 医学部, 教授 (70033321)

Co-Investigator(Kenkyū-buntansha) NUMACHI Yohtaro  Tohoku Univ.Sch.Med.Hosp.Assistant, 医学部・附属病院, 助手 (00261636)
INOSAKA Takao  Tohoku Univ.Sch.Med.Hosp.Assistant, 医学部・附属病院, 助手 (60241618)
OSAWA Mariko  Tohoku Univ.Postgraduate C.Student
Project Period (FY) 1992 – 1994
KeywordsEpilepsy / Kindling effect / Mossy fiber sprouting / Cell loss / Seizure injury / Hippocumpus / 海馬
Research Abstract

1. Mossy fiber sprouting and the cell loss in supragranular layr of dentate gyrus appeared independently of amygdala kindling in S.D.rats.
2. The sprouting and cell loss increased significantly after kindling along with long-term repetition of kindled generalized convulsive seizures.
3. Repeated electrical stimulation of the amygdala without inducing afterdis-charges neither produced sprouting nor cell loss in the hippocampus.
4. Cell loss may occur prior to emergence of mossy sprouting.
These results revealed that mossy fiber sprouting is not essential for development of kindling effect, and suggested that it may be a secondary change to seizure-induced hippocampal cell loss.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 大沢真理子、他: "獲得けいれん準備性の長期持続性と海馬の組織学的変化" てんかん研究. 13(印刷中). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato M・他: "Temponal lobe epilepsy" Japn J Psychiatry Neurology. 48. 203-204 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤光源: "てんかん患者と精神医学" International Epilepsy News. 116. 16-17 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤光源: "てんかんの最新外科学治療" 医学書院, 288 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤光源: "てんかん研究の最前線" ライフ サイエンス, 167 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osawa M., Inosaki T., Nakagawa T., Numachi Y.Yoshida S., Ito C., Tada S.and Sato M.: "Persistence of kindled seizure susceptibility and morphometric change in dentate gyrus of amygdala kindled rats." J.Japan Epilepsy Society. 13 : (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M., Miyasaka M.: "Temporal lobe epilepsy." Japn J.Neurol Psychiat. 48. 203-204 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M.: "Epileptic patients and psychaitry." International Epilepsy News. 116. 16-17 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M.: "Biological relationship of epilepsy to psychosis." Brain Sci Ment Dis. 4. 83-85 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M., Yamauchi T.: "Biological study on pathophysiology of epilepsy : secondary brain disorders following ictus." Japn J.Neurol Psychiat. 47. 223-224 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inosaka T., Osawa M., Yoshida S., Sato M.et al.: "Seizure stage, persistence of kindled epilepto-eptogenesis, and mossy fiber sprouting." Japn J.Neurol Psychiat. 47. 235-237 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M., Yamauchi T.: "Biological study on pathophysiology of epilepsy : the pathophysiology of periictal events." Japn J Neurol Psychiat. 46. 287-288 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueno T., Matsuoka H., Matsue Y.et al.: "Disturbance of visual information processing in temporal lobe epilepsy." Japn J Neurol Psychiat. 47. 344-345 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimoto K., Sato M.: "NMDA receptor complex and kindling mechanisms." Epilepsy Res. Suppl.9. 297-305 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M.: Experimental Epilepsy.Update Surgical Treatment of Epilepsy, pp.258-259, Igaku-syoin, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato M.: Current Status and Future of Epileptology.Current Topics in Epilepsy Research, 160-166

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wada J.A., Sato M., Morimoto K.: Neuromechanisms of Epilepsy, Sekai Hoken Tsuushinsya, (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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