1994 Fiscal Year Final Research Report Summary
Effect of Continuous Intraarterial Infusion of Vasodilator and Anticoagulant to Extend the Survial of a Pedicled Flap Through Unusual Routes in Rabbit
| Project/Area Number |
04454314
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | SHINSHU UNIVERSITY |
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Principal Investigator |
MATSUO Kiyoshi Shinshu University School of Medicine, Professor, 医学部, 教授 (20135156)
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| Project Period (FY) |
1992 – 1994
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| Keywords | FLAP / SURVIVAL LENGTH / CONTINUOS INTRAARTERIAL INFUSION / VASODILATOR / ANTICOAGULANT |
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| Research Abstract |
When a pedicled flap is extended over the safety length, the distal portion of the flap may necrose. To safely extend the survival length of the flap, surgical delay, intravenous and intraarterial administration of vasodilators and anticoagulants have been performed. As the intraarterial administration in flap surgery has a risk of thromboembolism, it has been rarely reported. In our experimental rabbit model, to preserve the main arterial inflow to the flap and to reduce the risk of thromboembolism, the infusion of PGE_1 was administered via a upstream branch of the nutrient artery in retrograde fashion, or via a nutrient artery of next neighbor vascular territory in the extended portion of the flap in advance fashion. Results showed that both the former and the latter route increases the vascularity and the survial length of the flap. In conclusion, it is important keeping anticoagulant condition in the flap until the revascularization between the flap and recipient site occurs as well as increasing vascularity, to extend the survival length of the flap.
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