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1993 Fiscal Year Final Research Report Summary

Efficacy of the combined therapy of stable strontium (Sr) with multidisciplinary treatment for advanced cancer

Research Project

Project/Area Number 04454326
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionGunma University

Principal Investigator

NAGAMACHI Yukio  Gunma University, School of Medicine Professor, 医学部, 教授 (30008289)

Co-Investigator(Kenkyū-buntansha) HASHIZUME Tatsuo  Gunma Univ.School of Medicine Lecturer, 医学部, 教務員 (50241899)
ASAO Takayuki  Gunma Univ.School of Medicine Assistant, 医学部, 助手 (40212469)
TAKENOSHITA Sei-ichi  Gunma Univ.School of Medicine Associate Professor, 医学部, 助教授 (10167489)
Project Period (FY) 1992 – 1993
KeywordsStable Strontium(Sr) / multidisciplinary treatment / cytoprotection / Immunochemotherapy
Research Abstract

The pupose of the present investigation is to elucidate the effect and cytoprotective mechanisms of Sr for biological response and to estabilish the clinical usefulness for the adjuvant cancer therapy. Administration of anti-cancer drugs or irradiation on non cancer-bearing rats increased serum ACTH, Cortisol and IAP levels. Such negative effects on the host's immunity were reduced by the combined administration of Sr with the anticancer drugs. Using the cancer-bearing rat models, Sr alone showed no effects on the tumor growth rate. However, combined adiministration of Sr, PSK and anti-cancer drugs significantly inhibited the tumor growth without reducing the host's immunity. The same results were obtained using the nude mouse models. Sr was indicated to act without affecting the T-cell function.
In conclusion, the effectiveness of Sr on multidisciplinary cancer treatment was suggested. Further study should be going on to identify the effector cells of Sr in the micromorphological and cytochemical aspects.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Takayuki Asao: "Eradication of Hepatic Metastases of Carcinoma 11-59 by Combination Chemoimmunotherapy with Liposomal Muramyl Tripeptide,5-Fluorouracil,and Leucovorin" CANCER RESEARCH. 52(15). 6254-6257 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Atsusi Takahashi: "Observation of O_2-generation in situ gastric mucosa of rats in the development of experimental acute gastric mucosal lesions" Cytoprotection & Cytobiology. 19. 260-266 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹之下 誠一: "免疫化学療法における内分泌系の変動について" 消化器癌の発生と進展. 4. 485-489 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seiichi Takenoshita: "Temporal changes in ACTH,cortisol,and IAP in rat under immunochemotherapy with 5-FU and Krestin" In vivo. 7(2). 131-134 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹之下 誠一: "癌集学的治療における Stable Strontium(Sr)併用の試み" Biomedical Research on Trace Elements. 4(2). 157-158 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tatsuo Shimura: "The study of tumor necrosis factor β gene polymorphism in lung cancer patients" Cancer February 15. 73(4)(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asao T.: "Eradication of hepatic metastasis of carcinoma H-59 by combination chemoimmunothepapy with liposomal tripeptide, 5-fluorouracil and leucovorin" Cancer Res.52. 6254-6257 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi A.: "Observation of O_2 generation in situgastric mucosa of rats in the development of experimental acute gastric mucosal lesions" Cytoprotection & Cytobiology. 19. 260-266 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takenoshita S.: "Endocrine system changes in immunochemotherapy" Proceedings of Japanese Research Society of Gastroenterological Carcinogenesis. 4. 485-489 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takenoshita S.: "Temporal changes in ACTH, cortisol, and IAP in rat under immunochemotherapy with 5-FU and Krestin" In vivo 7. (2). 131-134 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takenoshita S.: "Inhibitory effects of combined administration of UFT, PSK and Sr.on the intraperitoneal metastasis of carcinoma colon 26 in mice" Biomedical Research on Trace Elements. 4(2). 157-158 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimura T.: "The study of tumor necrosis factor beta gene polymorphism in lung cancer patients." Cancer. 73(4)in press. (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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