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1994 Fiscal Year Final Research Report Summary

Tumor associated gene in chromosomal translocation in acute leukemia

Research Project

Project/Area Number 04454568
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionUniversity of Tokyo

Principal Investigator

HAYASHI Yasuhide  Univ.of Tokyo (Hospital), Pediatrics, Associate Professor, 医学部(病), 講師 (30238133)

Co-Investigator(Kenkyū-buntansha) HIRAI Hisamaru  Univ.of Tokyo (Hospital), Internal Medicine, Associate Professor, 医学部(病), 講師 (90181130)
KOBAYASHI Miyuki  Univ.of Tokyo (Hospital), Pediatrics, Assistant Professor, 医学部(病), 助手 (60205391)
KAMOSHITA Shigehiko  Univ.of Tokyo (Hospital), Pediatrics, Professor, 医学部(病), 教授 (60048973)
BESSHO Fumio  Univ.of Tokyo (Hospital), Pediatrics, Associate Professor, 医学部(病), 助教授 (40010285)
Project Period (FY) 1992 – 1994
Keywordsacute leukemia / lymphoma / suppressor gene / translocation / E2A-PBX1 / TAL1 gene / MLL gene / TLS / FUS-ERG
Research Abstract

E2A-PBX1 chimeric mRNA,which was reported in t (1 ; 19)-acute lymphoblastic leukemia (ALL), was found in 10 of 40 ALL patients. p53 alteration was found in 2 of 20t (1 ; 19)-ALL at diagnosis, 4 of 4 at relapse and 4 of 5 cell lines. We conclude that p53 alteration is associated with relapse or progression. We examined TAL1 alteration in 99 hematological maligmacines and found the alteration in 10 T-ALL patients. Theses patients had similar immunophonotype, normal karyotype, good prognosis, resulting in a subset of T-ALL.TLS/FUS-ERG chimeric mRNA was found in all the 19t (16 ; 21)-acute myeloid leukemia (AML), 18 of whom died. We concluded that t (16 ; 21)-AML patient has a poor prognosis and should be treated by stem cell transplantation in the first remission. MLL gene analysis was preformed on leukemia with 11q23 abnormalities. We found that infant with MLL rearrangements was a poor prognosis. We also found 3 partner genes of MLL gene, AF-5alpha, CBP and p300 gene. We examined the role of these genes in the development of leukemia.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kikuchi A,et al.: "Clinical significance of TAL1 gene alteration in child hood T-cell acute lymphoblastic leukemia and lymphome" Leukemia. 7. 946-953 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu K,et al.: "An ets-related gene,ERG,is rearranged in human myeloid leukemia with t(16;21) chromosomal thranslocation" Proc Natl Acad Sci USA. 90. 10280-10284 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichikawa H,et al.: "An RNA-binding protein TLS/FUS is fused to FRG in human myeloid leukemia with t(16;21) chromosomal translocation" Cancer Res. 54. 2865-2868 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawamura M,et al.: "Mutation of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia." Blood. 85. 2546-2552 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohnishi H,et al.: "Homozygous deletion of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic" Blood. 86. 1269-1275 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taki T,et al.: "The t(11;16) (q23;p13) translocation in Myelodysplastic Syndrome Fuses the MLL gene to the CBP gene" Blood. 89. 3945-3950 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kikuchi A,Hayashi Y,Kobayashi S,Hanada R,Yamamoto K,Fujimoto J,Kaneko Y,Yamamori S.: "Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma." Leukemia. 7. 946-953 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu K,Ichikawa H,Tojo A,Kaneko Y,Maseki M,Hayashi Y,Ohira M,Asano S,Ohki M: "An ets-related gene, ERG,is rearranged in human myeloid leukemia with t (16 ; 21) chromosomal translocation." Proc Natl Acad Sci USA. 90. 10280-10284 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichikawa H,Shimizu K,Hayashi Y,Ohki M.: "An RNA-binding protein TLS/FUS is fused to FRG in human myeloid leukemia with t (16 ; 21) chromosomal translocation." Cancer Res. 54. 2865-2868 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawamura M,Hayashi Y,Kobayashi S,Kikuchi A et al.: "Mutations of the p53 and ras genes in childhood t (1 ; 19)-acute lymphoblastic leukemia." Blood. 85. 2546-2552 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohnishi H,Kawamura M,Ida K,Hanada R,Hayashi Y,et al.: "Homozygous deletion of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia." Blood. 86. 1269-1275 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomohiko Taki, Masahiro Sako, Masahiro Tsuchida, and Yasuhide Hayashi: "The t (11 ; 16) (q23 ; p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene" Blood. Vol 89, No 11 (June 1). 3945-3950 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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