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1994 Fiscal Year Final Research Report Summary

Induction of immunological tolerance by cell adhesion moleculerelated substances.

Research Project

Project/Area Number 04557020
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

UEDE Toshimitsu  Hokkaido University, Institute of Immunological Science, Professor, 免疫科学研究所, 教授 (00160185)

Co-Investigator(Kenkyū-buntansha) SUDO Tetsuo  Toray Industries, Inc., Basic Research Laboratories, Principal Researcher, 基礎研究所, 主任研究員
YASUDA Keisyu  Hokkaido University, Department of Medicine University Hospital, Professor, 医学部・付属病院, 教授 (60125359)
Project Period (FY) 1992 – 1994
KeywordsTransplantation / Rejection / Cell Adhesion Molecule / Immunological Torerance / CTLA4
Research Abstract

The purpose of this study was to generate soluble forms of cell adhesion molecules which can efficiently inhibit the costimulatory signals for T cell activation and proliferation. We generated a fusion protein consisting of a Fc portion of human IgG_1 or human IgM and an extracellular portion of mouse CTLA4 (CTLA4-IgG and CTLA4-IgM,respectively).
CTLA4-IgM efficiently inhibited the T cell proliferation induced by mixed lymphocyte reaction (MLR) as compared to CTLA4-IgG.Furthermore, the combination of low does FK506 and CTLA4-IgM (2.3mug/ml) resulted in significant prolongation of cardiac allograft surviral (C57BL/6 into CBA/J), where as cardiac alloglaft surviral in recipients treated with FK506 plus CTLA4-IgG (2.3mug/ml) resulted in moderate prolongation of grafts.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Morikawa,M.: "Cardiac allografts in rat recipiemts with simultaneous use of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies leads to accelerated graft loss." Immunopharmacology. 28. 171-182 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森川雅之: "移植免疫と細胞接着" 侵襲と免疫. 3. 89-94 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamiya,Y.: "Protective efect of monoclonal antibodies against LFA-1 and ICAM-1 on myocardial reperfusion injury following global ischemia in rat hearts." Immunopharmacology. 29. 53-63 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamikubo,Y.: "Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and reperfusion of isolated hearts." Immunopharmacology. 29. 261-271 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森川雅之: "移植と細胞接着" 細胞. 27. 8-13 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森川雅之: "臓器移植と免疫反応" Medicina. 32. 545-549 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山田陽: "Newメディカルサイエンス・移植免疫の最前線 磯部光章編" 羊土社, 166 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morikawa, M., Tamatani, T., Miyasaka, M.and Uede, T.: "Cardiac allografts in rat recipients with simultaneous use of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies leads to accelerated graft loss." Immunopharmacology. 28. 171-182 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, A.and Murakami, M.: "A generation of a soluble form of CTLA4-IgM." Sapporo Medical Journal. 63. 231-237 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamiya, Y., Yamamoto, N.and Uede, T.: "Protective effect of monoclonal antibodies against LFA-1 and ICAM-1 on myocardial reperfusion injury following global ischemia in rat hearts." Immunopharmacology. 29. 53-63 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamikubo, Y., Murakami, M., Imamura, M., Murashita, T., Yasuda, K.and Uede, T.: "Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and reperfusion of isolated hearts" Immunopharmacology. 29. 261-271 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, A., Murakami, M., Ijima, K., Yagita, H., Okumura, K., Komatsu, S.and Uede, T.: "Long-term acceptance of major histocompatibility complex mismatched cardiac allograft induced by low does of CTLA4-IgM plus FK506." (Submitted).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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