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1993 Fiscal Year Final Research Report Summary

Development of a catheter-type ultrasound transmission system for augmentation of coronary thrombolysis

Research Project

Project/Area Number 04557042
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKagawa Medical School

Principal Investigator

MORITA Hisaki  Kagawa Medical School, Second Department of Internal Medicine, Assistant Professor, 医学部附属病院, 講師 (70145051)

Co-Investigator(Kenkyū-buntansha) NINOMIYA Shizuo  ALOKA Ltd., Third Department of Technology, Chief of the Department, 第三技術部, 部長
NOZAKI Shiro  Kagawa Medical School, Second Department of Internal Medicine, Research Associat, 医学部附属病院, 助手 (80243773)
HIRABAYASHI Koichi  Kagawa Medical School, Second Department of Internal Medicine, Research Associat, 医学部附属病院, 助手 (80240894)
SENDA Shoichi  Kagawa Medical School, Second Department of Internal Medicine, Associate Profess, 医学部附属病院, 助教授 (30145049)
MATSUO Hirohide  Kagawa Medical School, Second Department of Internal Medicine, Professor, 医学部, 教授 (90028514)
Project Period (FY) 1992 – 1993
KeywordsThrombolysis / Ultrasound / Cardiac catheter
Research Abstract

We attempted to develop a catheter-type ultrasound transmission system for augmentation of coronary thrombolysis. In 1992, we developed a closed circuit for cooling a flexible horn to transmit ultrasound which radiated heart in operation, and performed an in vivo study using dogs in which thrombus was formed in the femoral artery. In 1993, the following in vivo study was performed : complete obstruction by thrombus was made in bilateral femoral arteries and ultrasound was transmitted to one site of thrombus formation under t-PA administration. In some cases, recanalization was occurred earlier at the site exposed than another control site. However, the effect of ultrasound exposure was not definite. Therefore we conducted an in vitro experiment to obtain basic data concerning the magnitude and duration of ultrasound exposure. As a result, ultrasound exposure of 1MHz, 1W/cm^2, and of the duration of 30 minutes under administration of t-PA and an echocardiographic contrast agent caused significant decrease in the volume of thrombus, and microscopic examination revealed many scattered small cavities in the thrombus exposed. Based on these findings, further in vivo study is going on.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Mizushige Katsufumi, et al: "Effects of short-term of sublingual nifedipine on coronary arterial wall elastic properties:Evaluation by intravascular ultrasound" J Cardiovasc Pharmacol. 29(4). 508-514 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizushige Katsufumi, et al: "Left ventricular diastolic filling dynamics during isometric exertion in syndrome X assessed with Doppler flowmetry" Angiology. 48(10). 871-881 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Motoi Koji, et al: "Stiffness of human arterial wall assessed by intravascular ultrasound" J Cardiol. 25(4). 189-197 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikawa Kay, et al: "Cyclic alteration in atheroma plaque morphology observed by intracoronary ultrasound:Initiation mechanism of acute myocardial infarction" J Cardiol. 27(3). 95-101 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita Hisaki, et al: "A new noninvasive method of diagnosing vasospastic angina based on dilation response of the left main coronary artery to nitroglycerin as measured by echocardiograpy" J Am Coll Cardiol. 27(6). 1450-1457 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Motoi, Koji: "Stiffness of human arterial wall assessed by intravascular ultrasound." J Cardiol. 25 (4). 189-197 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikawa Kay: "Cyclic alteration in atheroma plaque morphology observed by intracoronary ultrasound : Initiation mechanism of acute myocardial infarction." J Cardiol. 27 (3). 95-101 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita Hisaki: "A new noninvasive method of diagnosing vasospastic angina based on dilation response of the left main coronary artery to nitroglycerin as measured by echocardiography." J Am Coll Cardiol. 27 (6). 1450-1457 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizushige Katsufumi: "Effects of short-term administration of sublingual nifedipine on coronary arterial wall elastic properties : Evaluation by intravascular ultrasound" J Cardiovasc Pharmacol.29 (4). 508-514 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizushige Katsufumi: "Left ventricular filling dynamics during isometric exertion in syndrome X assessed with Doppler flowmetry." Angiology. 48 (10). 871-881 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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