1994 Fiscal Year Final Research Report Summary
癌細胞特異糖鎖抗原による慢性関節リウマチ患者に対する感作療法
| Project/Area Number |
04557066
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
OCHI Takahiro Osaka Univ. Medicine Professor, 医学部, 教授 (80112035)
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| Co-Investigator(Kenkyū-buntansha) |
OWAKI Hajime Osaka Univ. Medicine Assistant professor, 医学部, 助手 (60223872)
KIMURA Tomoatu Osaka Univ. Medicine Lecturer, 医学部, 講師 (80167379)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Rheumatoid arthritis / Oncofetal membrane marker / Carbohydrate / Sensitization |
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| Research Abstract |
As reported by us, a new myeloid cell population with an oncofetal membrane marker, dimeric Lex (di-Lex ; III3FucV3FucnLc6) , was found in the epiphyseal bone marrow adjacent to the involved joints of patients with severe rheumatoid arthritis (RA) .Patients with RA recieved intradermal (id) injections of di-Lex incorporated in liposome or of high molecular weight glycoprotein, or tumor assosiated carbohydrate antigen (TCA) , containing the same carbohydrate epitope as di-Lex. The epiphyseal myeloid cells were reduced or sometimes eliminated during id injection. In random trials of id injection, observation under clinical and laboratory conditions showed improvement in 63% (17/27) of the patients treated for 6 months with appropriate doses of di-Lex (III3FucnLc4) , and in 72% (31/43) of those treated with an identical protocol for TCA.However, id injection with monomeric Lex had no effect.
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[Publications] Hayashida, K.・, Ochi, T.・, Fujimoto, M., Owaki, H., Shimaoka, Y.・, Ono, K., Matsumoto, K: "Bone marrow changesin adjuvant-inducedand collagen-inducedarthritis." Arthritisand Rheumatism. 35. 241-245 (1992)
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「研究成果報告書概要(欧文)」より
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[Publications] Fujimoto, M., Hayashida, K., Ochi, T., Owaki, H., Shimaoka, Y., Ono, K: "Fluctuation of interleukin-1and-6 activity in bone marrow serumin collagen-inducedarthritis in rats." Biomedical Research. 13. 243-251 (1992)
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「研究成果報告書概要(欧文)」より
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[Publications] Kaisho, T., Oritani, K., Ishikawa, I., Tanabe, M., Muraoka, O., Ochi, T: "Human bone marrow stromal cell lines from mueloma and rheumatoidarthritis that can supportmurine PRE-B cell grouwth." The Journal of Immunology. 149. 4088-4095 (1992)
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「研究成果報告書概要(欧文)」より
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[Publications] Ochi, T., Hakomori, S., Fujimoto, M., Okamura, M., Owaki, H., Wakitani, S., Shimaoka, Y., Hayashida, K., Tomita, K., Kawamura, S., Ono, K.: "Therapeutic Effect of Intradermal Injections with Difucosyl Lactosamine (Dimeric Lex) on Patients with Rheumatoide Arthritis." The Journal of Rheumatology. 20. 2038-2045 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] Furumitsu, Y., Yukioka, K., Kojima, K., Yukioka, M., Shichikawa, K., Ochi, T., Matui-Yuasa, I., Otani, S., Nishizawa, Y., Morii, H.: "Levels of Urinary Polyamines in Patients with Rheumatoid Arthritis." The Journal of Rheumatology. 20. 1661-1665 (1993)
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[Publications] Tanabe, M., Ochi, T., Tomita, T., Suzuki, R., Sakata, T., Shimaoka, Y., Nakagawa, S., Keiro, O.: "Remarkable Elevation of Interleukin6 and Interleukin8 Levels in the Bone Marrow Serum of Patients with Rheumatoid Arthritis." The Journal of Rheumatology. 21. 830-835 (1994)
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[Publications] Tomita, T., Kashiwagi, N., Shimaoka, Y., Ikawa, T., Tanabe, M., Nakagawa, S., Kawamura, S., Denno, K., Owaki, H., Ochi, T.: "Phenotypic Characteristics of Bone Marrow Cells in Patients with Rheumatoid Arthritis." The Journal of Rheumatology. 21. 1608-1614 (1994)
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