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1994 Fiscal Year Final Research Report Summary

METHODS FOR DEGRADING MUTAGENS

Research Project

Project/Area Number 04557109
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

HAYATSU Hikoya  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (10012593)

Co-Investigator(Kenkyū-buntansha) TSUIKI Hisanaga  DAIWABOU CREATE,RESEARCHER, テクノステーション, 研究員
SAITOU Yutaka  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (20025711)
Project Period (FY) 1992 – 1994
KeywordsMUTAGEN / DEGRADATION / Fe-OCTACARBOXYPHTHALOCYANINE / RESIN BEARING METALLOPORPHYRIN / CHLOROPHYLLIN / HETEROCYCLIC AMINE
Research Abstract

1) Some of heterocyclic amines (Trp-P-1, Trp-P-2 and 2-amino-alpha-carboline) were degraded by the action of Fe-octacarboxyphthalocyanine-rayon(Fe-ocpc-rayon) in aqueous solutions. The presence of hydrogen peroxide in the solutions accelerated the degradation. Mutagens extracted from tabacco smoke also underwent the degradation by the Fe-ocpc-rayon.
2) IQ was converted to red colored dimer by the action of a resin bearing Mn- or Fe-tetrakis (sulfonyl) porphine ligand in the presence of hydrogen peroxide.
3) Hemin and chlorophyllin stimulated the degradation of benzo (a) pyrene-7,8-diol-9,10 epoxide, a potent carcinogenic metabolite of benzo(a)pyrene.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] H. Hayatsu: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J. Chromatography. 497. 37-56 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Hayatsu: "Dietary inhibitors of mutagenesis and carcinogenesis." Chemoprevention of Cancer. 387-418 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Hayatsu: "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens." Mutation Res.290. 79-85 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Hayatsu: "Suppressing effect of Lactobacillus cassei administration on the urinary mutagenicity arising from ingestion of fried ground beef." Cancer Letters. 73. 173-179 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Hayatsu: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms III. 387-418 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Negishi: "Inhibitory activity of chlorophyllin on the mutagenicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.HAYATSU: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J.Chromatography. 497. 37-56 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.HAYATSU: "Dietary inhibitors of mutagenesis and carcinogenesis" Chemoprevention of Cancer. 387-418 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.HAYATSU: "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens." Mutation Research. 290. 79-85 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.HAYATSU: "Suppressing effect of Lactobacillus cassei administration on the urinary mutagenicity arising from ingestion of fried ground beef." Cancer Letters. 73. 173-179 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.HAYATSU: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms. III. 87-418 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.NEGISHI: "Inhibitory activity of chlorophyllin on the mutagenicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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