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1993 Fiscal Year Final Research Report Summary

Brain stem mechanisms for generation of vertical fast eye movement

Research Project

Project/Area Number 04670062
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionHokkaido University

Principal Investigator

FUKUSHIMA Kikurou  Hokkaido University School of Medicine Associate Professor, 医学部, 助教授 (70091486)

Project Period (FY) 1992 – 1993
KeywordsVestibular nystagmus / Semicircular canal / Eye movement / Midbrain / Interstitial nucleus of Cajal / Saccade / Cat
Research Abstract

It is well known that vestibular nystagmus evoked by head rotation occurs in the plane specific to that in which head rotation was applied in three-dimensional space. Although burster-driving neurons (BDN) habe been demonstrated for a quick phase of horizontal nystagmus (see Ref. 18), it is as yet unknown where the counterpart for vertical nystagmus is located. We searched for neurons in the rostral midbrain in alert cats that showed the characteristic discharge pattern required for BDNs(Kitama et al 1992) for vertical eye movement. Two groups of neurons were found in our study. Downward BDNs(n=48)received anterior canal excitation from the contralateral side with short latency ; upward BDNs(n=21) received posterior canal excitation. Mean lead time for the burst activity before fast eye movement was 30 msec for both saccades and vestibular fast phases for both groups of neurons. All of them had irregular resting discharge rates, and some showed eye positon sensitivity toward the direction opposite to their on-direction.
Downward BDNs were found in the interstitial nucleus of Cajal and its close vicinity ; whereas upward BDNs were found more laterally and caudally.
Bilateral muscimol infusion (0.3 mug for each side) into the downward BDN areas resulted in a selective loss of downward fast eye movement in addition to the failure of holding vertical eccentric eye position ; bilateral infusion into the upward BDN areas decreased number of upward fast eye movement significantly.
Horizontal eye movements were not impaired significantly by these imjections.
These results suggest specific involvement of vertical BDNs in generating vertical fast eye movement.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Fukushima,K.: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci.Res.12. 536-544 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "Ocular torsion produced by unilateral chemical inactivation of the inters titial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci.Res.13. 301-305 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "The neuronal substrate of integration in the oculomotor system." Prog.Neurobiol.39. 609-639 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci.Res.15. 299-303 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "Responses of floccular Purkinji cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert cats." Neurosci.Res.17. 297-305 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko,C.R.S.: "Burst driver neurons in the mesencephalon of the trained rhesus monkey." Neurosci.Abst.19. 859 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "Vestibular and brain stem control of eye,head and body movement." Japan Scientific Societies Press,Karger, 466 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima,K.: "Contemporary ocular motor and vestibular research:A tribute to David A Robinson" Georg Thieme Verlag Stuttgart(in press), (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima, K., Fukushima, J., et al.: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci. Res.12. 536-544 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima, K., Ohashi, T., et al.: "Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci. Res.13. 301-305 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima, K., Kaneko, CRS, et al.: "The neuronal substrate of integration in the oculomotor system." Prog. Neurobiol.39. 609-639 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima, K., Fukushima, J.: "The interstitial nucleus of Cajal is involved in generating downward fast eye movement in alert cats." Neurosci. Res.15. 299-303 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima, K., Buharin EV., et al.: "Responses of floccular purkinje cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert cats." Neurosci. Res.17. 297-305 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko, CRS, Fukushima, K.: "Burst driver neurons in the mesencephalon of the trained rhesus monkey." Neurosci. Abst.19. 859 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K., Fukushima K.: Vestibular and brain stem control of eye, head and body movement.Japan Scientific Societied Press, Karger, 466 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima, K., Buharin, E.V., et. al.: Contemporary ocular motor and vestibular research : A tribute to David A Bobinson. Georg Thieme Verlag Stuttgart (in press),

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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