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1993 Fiscal Year Final Research Report Summary

Microneurographic analysis on age-related changes in sympathetic nerve

Research Project

Project/Area Number 04670092
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionNagoya University

Principal Investigator

MANO Tadaaki  Research Institute of Environmental medicine, Departmenf of Autonomic andBehavioral Neurosciences Nagoya Univ. Prafessor, 環境医学研究所, 教授 (30023659)

Co-Investigator(Kenkyū-buntansha) IWASE Satoshi  Research Institute of Environmental medicine, Department of Autonomic andBehavio, 環境医学研究所, 助手 (90184879)
Project Period (FY) 1992 – 1993
Keywordssympathetic nerve activity / aging / microneurography / positional change / water immersion / sleep apnea / sweating / skin blood flow
Research Abstract

In order to clarify the effect of aging on sympathetic nerve activity in humans, we recorded muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA) by applying microneurography from subjects of various age-groups, and analyzed the age-related changes of in MSNA and SSNA under different environmental conditions. We also anlyzed the effect of aging on gender difference of resting activity and responsiveness to orthostasis of MSNA.
1. Effect of aging on resting activity and responsiveness to orthostasis of MSNA.Subjects were 41 Healthy men. The resting activity increased with advancing age, and a linear correlation was found between age and resting activity. The responsiveness to orthostasis decreased with advancing age, and an inverse correlation was observed between age and responsiveness. 2. Effect of aging on gender difference in resting activity and responsiveness to orthostasis of MSAN.Subjects were 40 men and 25 women(age : 21-25 years)for young group, a … More nd 8 men and 7 women(age : 65-78 years)for elderly. The gender difference in resting activity and responsiveness to orthostasis of MSNA observed in young groups disappeared in the elderly. 3. Effect of aging on MSNA suppression induced by water immersion. Subjects were 16 men aged 19 to 67 years. Suppression rate of MSNA induced by head-out water immersion was attenuated with advancing age. 4. MSNA response during sleep apnea in the elderly. Subjects were three elderly men. A remarked enhancement of MSNA was observed during sleep apnea accompanied with an elevation of systemic blood pressure. 5. Effect of aging on SSNA and effector response. The effector response to SSNA including sweating and vasoconstriction was reduced in 70-year-old man as compared with young subjects.
MSNA plays an important role in regulation of blood pressure. The increased MSNA with advancing age may be associated with a rise in systemic arterial blood pressure in the elderly. The decreased responsiveness of MSNA to positional change or head-out water immersion with advancing age indicates a reduced neural regulation no compensatory mechanism against body fluid shift induced by these loads. SSNAplays an essential role in thermoregulation. The attenuated effector responses to SSNA suggest a reduced function of effector organs, e.g. sweet glands or presphincter of skin vessels and/or receptors in the effector organs. Less

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 岩瀬敏: "加齢に伴う循環動態の変化." 自律神経. 30. 228-233 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwase,Satoshi: "Age-related changes and gender difference in sympathetic outflow to muscles against gravitational stress in humans." In:Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992,ed by Matsui N,Seo H.249-258 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe,Takemasa: "Assessment of sympathetic nerve activity controlling blood pressure in the elderly using head-up tilt." Environmental Research. 62. 251-255 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 美和千尋: "水浸時におけるヒトの筋交感神経活動の抑制反応に対する加齢の影響." 環研年報. 43. 65-68 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 美和千尋: "水浸時におけるヒトの筋交感神経活動の抑制反応に対する加齢の影響." 自律神経. 30. 16-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mano,Tadaaki: "Microneurographic analysis of sympathetic nerve activity in humans under simulated microgravity." Proceedings of the 1st International Workshop,“Space and Underwater Neurology",Messina-Taormina,Italy. 1-5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miwa,Chihiro: "Age-related changes of sympathetic outflow to muscles in humans during head-out water immersion." In:Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992,ed by Matsui M,Seo H. 249-258 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe,Takemasa: "Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly" Journal of the Autonomic Nervous System. 37. 223-226 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe,Takemasa: "Muscle sympathetic nerve activity during sleep apnea in the elderly." In:Sleep Apnea and rhonchopathy,ed.by Togawa K,Katayama S,Hishikawa Y,Ohta Y,Horie T,Karger,Basel. 112-117 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwase,Satoshi: "Age-related changes in vasoconstrictive and sudomotor responses to the skin sympathetic nerve activity in humans." Environmental Medicine. 37. 103-106 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 間野忠明: "第6章「高齢者のからだ-環境への適応-」「長寿を考える」第一法規 pp.53-67" 名古屋大学公開講座委員会 編, 217 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 間野忠明: "「水浸時における交感神経活動と循環動態の加齢変化」長寿科学総合研究 平成4年度研究報告Vol.3老年病各論 pp.57-60." 長寿科学総合研究費中央事務局 編, 498 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwase, S.: "Age-related changers in cardiovascular dynamics(in Japanese)" The Autonomic Nervous System. 30. 228-233 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase, S., Mano, T., Saito, M, Watanabe, T., Sugiyama, Y., Suzuki, H.: "Age-related changes and gender difference in sympathetic outflow to muscles against gravitational stress in humans" Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992, ed. by Matsui N, Seo H.249-258 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano, T.: "Ch.6, "Physiology of the Elderly, -Adaptation to Environment-"(in Japanese)" Committee on Nagoya University Open Seminar ed., Longevity, Daiichi Houki. 53-67 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, T., Kobayashi, F., Furui, H., Tanaka, T., Horibe, H., Takeshita, N., Iwase, S., Mano, T.: "Assessment of sympathetic nerve activity controlling blood pressure in the elderly using head-up tilt" Environmental Research. 62. 251-255 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miwa, C., Iwase, S., Mano, T., Saito, M., Sugiyama, Y., Suzuki, H.: "Age-related changes in sympathetic outflow to muscles in humans during head-out water immersion.(in Japanese)" Annals of Research Institute of Environmental Medicine, Nagoya University. 43. 65-68 (1662)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miwa, C., Iwase, S., Mano, T., Saito, M., Sugiyama, Y., Suzuki, H.: "Age-related changes in sympathetic outflow to muscles in humans during head-out water immersion. (in Japanese)" The Autonomic Nervous System. 30. 16-23 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano, T., Miwa, C., Iwase, S., Matsukawa, T., Koga, K., Sugiyama, Y., Suzuki, H.: "Microneurographic analysis of sympathetic nerve activity in humans under simulated microgravity." Proceedings of the First International Workshop, "Space and Underwater Neurology", Messina-Taormina(Italy). (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano, T.: "Age-related changes in sympathetic nerve activity and cardiovascular dynamics during water immersion.(in Japanese)" Research Report on Longetivity Research of 1992. vol.3, Special Geriatrics. 57-60 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miwa, C., Iwase, S., Mano, T., Saito, M., Koga, K., Sugiyama, Y., Suzuki, H.: "Age-related changes of sympathetic outflow to muscles in humans during head-out water immersion" Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992, ed. by Matsui N, Seo H.249-258 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, T., Mano, T., Iwase, S., Sugiyama, Y., Okada, H., Takeuchi, S., Furui, H., Kobayashi, F.: "Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly" Jounal of the Autonomic Nervous System. 37. 223-226 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, T., Mano, T., Iwase, S., Sugiyama, Y., Okada, H., Takeuchi, S., Tanaka, T., Furui, H., Kobayashi, F., Horibe, H.: "Muscle sympathetic nerve activity during sleep apnea in the elderly" Togawa K, Katayama S, Hishikawa Y, Ohta Y, Horie T, eds, Sleep Apnea and Rhonchopathy, Basel, Karger. 112-117 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase, S., Mano, T., Sugenoya, ., Sugiyama, Y., Matukawa, T., Okamoto, T., Yamamoto, K.: "Age-related changes in vasoconstictive and sudomotor responses to the skin sympathetic nerve activity in humans" Environmental Medicine. 37. 103-106 (1993)

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      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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