1993 Fiscal Year Final Research Report Summary
The human plasma glutathione peroxidase gene ; organization, nucleotide sequence and localization to chromosome 5q32.
| Project/Area Number |
04670169
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokai University School of Medicine |
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Principal Investigator |
YOSHIMURA Shinichi Assistant Professor Department of Molecular Life Science, 医学部, 講師 (30230808)
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| Co-Investigator(Kenkyū-buntansha) |
MORIUCHI Tetsuya Associate Professor Department of Molecular Life Science, 医学部, 助教授 (20174394)
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| Project Period (FY) |
1992 – 1993
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| Keywords | glutathione peroxidase / gene / chromosome mapping / human / plasma type / selenium |
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| Research Abstract |
A genomic clone encoding the human plasma glutathione peroxidase (PGPx), amajor enzyme reducing lipid hydroperoxide and hydrogen peroxide in plasma, was isolated and 5618 nucleotides were determined. The nucleotide sequence data revealed that the PGPx gene is composed of five exons spanning approximately 10 kilobases. Primer extension experiments mapped the transcription start point at 298 nucleotides upstream from the predicted translation initiation codon. Seventeen nucleotides upstream from the polyadenylation site of the gene, an uncanonical polyadenylation signal, AGTAAA, was found. The human PGPx gene was localized on chromosome 5 band q32 by fluorescence in situ hybridization.
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Research Products
(15 results)
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[Publications] S.Yoshimura, H.Suemizu, Y.Taniguchi, K.Watanabe, Y.Nomoto, Y.Katsuoka, S.Arimori and T.Moriuchi: "Tissue specific expression of human plasma glutathione peroxidase gene in kidney and decreased production of the enzyme in patients with chronic renal failure." Oxygen Radicals(K.Yagi, M.Kondo, E.Niki and T.Yoshikawa, eds.), Elsevier Science Publishers B.V.545-548 (1992)
Description
「研究成果報告書概要(欧文)」より
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