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1993 Fiscal Year Final Research Report Summary

Overlap of paraneoplastic granulocytosis and hypercalcemia

Research Project

Project/Area Number 04670188
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionTokai University

Principal Investigator

NAKAMURA Masato  Tokai University School of Medicine Assistant Professor, 医学部, 講師 (00164335)

Co-Investigator(Kenkyū-buntansha) UEYAMA Yoshito  Tokai University School of Medicine Associate Professor, 医学部, 助教授 (30072408)
Project Period (FY) 1992 – 1993
KeywordsColony-Stimulating Factor / Parathyroid Hormone related Protein / Leukocytosis / Hypercalcemia / Tumor Xenograft
Research Abstract

Human neoplasm rarely accompanies with peripheral blood granulocytosis and humoral hypercalcemia. These paraneoplastic syndromes are essentially different entities. However, a few malignant neoplasms accompany both paraneoplastic syndromes. In this study, the mechanisms for overlap of the PB granulocytosis and hypercalcemia were examined by molecular biological analysis in the human tumor xenografts established in nude mice. We isolated 6 human malignant tumor xenografts which accompany with both PB granulocytosis and hypercalcemia in their host animals. All the 6 human xenografts co-express granulocyte-colony stimulating factor (G-CSF) and parathyroid hormone related protein (PTHrP) gene. Biologically active G-CSF protein secretion were confirmed in the sera of the host animals. And, the PTHrP transcripts revealed molecular heterogeneity in these tumor xenografts, suggesting of the alternative splicing mechanisms. One of the 6 xenograft (LC-GP-JCK) contain activated K-RAS oncogene (codon 12). The relationship between co-expression of G-CSF/PTHrP gene and RAS oncogene activation is interesting. Further analysis will be required.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Satoh,H.: "Bladder carcinoma producing granulocyte colony-stimulating factor:A case report" The Journal of Urology. 149. 843-845 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katoh,Y.: "Autnomous production of granulocyte-colony stimulating factor in tumour xenograft associated with leukocytosis" British Jouranl of Cancer. 68. 715-719 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoh, H., et al.: "Bladder carcinoma producing granulocyte colony-stimulating factor : A case report." The J.Urol.149. 843-845 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katoh, Y., Nakamura, M., Ohnishi, Y., Shimamura, K., Ueyama, Y., and Tamaoki, N.: "Autonomous production of granulocyte-colony stimulating factor in tumor xenografte associated with leukocytosis." Br.J.Cancer. 68. 715-719 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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