• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

Clinicopathologic and biologic study of the neoplasms arising from the T-cell area of the lymph node.

Research Project

Project/Area Number 04670196
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

NAKAMURA Shigeo  MD, Aichi Cancer Center Research Institue, Stuff., 研究員 (80180363)

Project Period (FY) 1992 – 1993
KeywordsLymph node / T-cell area / Neoplasm / Clinicopathology / Biology / Peripheral T-cell lymphoma / Dendritic cell tumor
Research Abstract

In the present study, we investigated the tumor arsing from the T-cell area of the lymph node. Peripheral T-cell lymphoma (PTCL) was classified according to the updated Kiel (Suchi) classification. The clinicopathologic, phenotypic and genotypic findings of node-based, low-grade, PTCL (AILD type, T-zone type, and lymphoepithelioid type) were summarized (Cancer 1991 ; 67 : 2565). The proportion of the neoplastic cells (CD4+, Ki67+) in these tumors was demonstrated to have a relatively good correlation with the clonal TCRbeta rearrangement (Cancer 1993 ; 72 : 1762, Acta Pathol Jpn 1993 ; 43 : 396). In the process of the (Cancer 1993 ; 71 : 249). An accumulation of the additional 10 cases of this tumor suggested them to constitue a unique subgroup regarded as high-grade lymphoma, although some might be of natural killer (NK) cell lineage.
Interdigitating cell sarcoma was an extremely rare tumor arising from the paracortical area in the lymph node (Cancer 1988 ; 61 : 562). Recently, we described the histologic and immunophenotypic features of four cases of this tumor (Pathol Int 1994 ; in press).
We are going to examine the participation of oncogene and antioncogene in those tumors.

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Nakamura S,et al.: "Interdigitating cell sarcoma.A morphologic and immunologic study of lymph node lesion of four cases." Pathol Int. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S,et al.: "Imprint cytology of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the thymus." Diag Cytopathol. 9. 665-667 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S,et al.: "Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese." Cancer. 72. 1762-1772 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kojima M,et al.: "Malignant lymphoma of Waldeyer's ring.A histological and immunological study." APMIS. 101. 537-544 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S,et al.: "Phenotypic analysis of peripheral T-cell lymphoma among the Japanese." Acta Pathol Jpn. 43. 396-412 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki S,et al.: "Alterations of integrin expression in human lung cancer." Jpn J Cancer Res. 84. 168-174 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuda R,et al.: "Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues." Am J Pathol. 142. 339-346 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakagawa A,et al.: "Clinicopathologic study of primary mediastinal non-lymphoblastic non-Hodgkin's lymphomas." Acta Pathol Jpn. 43. 44-54 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kojima M,et al.: "Abscess-forming granulomatous lymphadenitis:histo-logical typing of suppurative granulomas and clinico." Acta Pathol Jpn. 43. 11-17 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S,et al.: "Aggressive rectal lymphoma of large granular lymphocytes with histologic feature of angiocentric growth." Cancer. 71. 249-256 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kurita S,et al.: "Mediastinal diffuse large cell lymphoma of B-cell phenotype with azurophilic granules." Int J Hematol. 56. 51-58 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wajjwalku W,et al.: "Low frequency of rearrangements of the ret and trk protooncogenes in Japanese thyroid papillary carcinomas." Jpn J Cancer Res. 83. 671-675 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kojima M,et al.: "Malignant lymphomas of the nasal cavity and paranasal sinuses.A clinicopathologic and immunologic..." Acta Pathol Jpn. 42. 333-338 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto Y,et al.: "Phenotypic and genotypic lineage switch of a lymphoma with shared chromosome translocation and T-cell..." Jpn J Cancer Res. 83. 465-476 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takagi N,et al.: "A phenotypic and genotypic study of three node-based,low-grade peripheral T-cell lymphoma:angioimmuno..." Cancer. 69. 2571-2582 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S,et al.: "Peripheral T-cell lymphoma of AILD type involving gastrointestinal tract.A morphologic,phenotypic..." Acta Pathol Jpn. 42. 141-149 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takagi N,et al.: "Malignant lymphoma of mucosa-associated lymphoid tissue arising in the thymus of the patient with..." Cancer. 69. 1347-1355 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S, et al.: "Interdigitating cell sarcoma. A morphologic and immunologic study of lymph node lesion of four cases." Pathol Int. in press. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S, et al.: "Imprint cytology of lowgrade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the thymus. A case report." Diac Cytopathol. 9. 665-667 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S, et al.: "Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese." Cancer. 72. 1762-1772 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima M, et al.: "Malignant lymphoma of Waldeyer's ring. A histological and immunological study." APMTS. 101. 537-544 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S, et al.: "Phenotypic analysis of peripheral T-cell lymphoma among the Japanese." Acta Pathol Jpn. 43. 396-412 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki S, et al.: "Alterations of integrin expression in human lung cancer." Jpn J Cancer Res. 84. 168-174

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda R, et al.: "Expression of the c-kit protein in human solid tumors and in coresponding fetal and adult normal tissues." Am J Pathol. 142. 339-346 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakagawa A, et al.: "clinicopathologic study of primary mediastinal nonlymphoblastic and non-Hodgkin's lymphomas among the Japanese." Acta Pathol Jpn. 43. 44-54 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima M, et al.: "Abscess-forming granulomatous lymphadenitis : Histologic typing of suppurative granulomas and clinicopathologic findings with special reference to cat scratch disease." Acta Pathol Jpn. 43. 11-17 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S, et al.: "Aggressive rectal lymphoma of large garnular lymphocytes with histologic feature of angiocentric growth pattern." Cancer. 71. 249-256 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kurita S, et al.: "Mediastinal diffuse large cell lymphoma of B-cell phenotype with azurophilic granules." Int J Hematol. 56. 51-58 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wajjwalku W, et al.: "Low frequency of rearrangements of the ret and trk protooncogenes in Japanese thyroid papillary carcinomas." Jpn J Cancer res. 83. 671-675 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima M, et al.: "Malignant lymphomas of the nasal cavity and paranasal sinuses. A clinicopathologic and immunohistochemical study." Acta Pathol Jpn. 42. 333-338 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto Y, et al.: "Phenotypic and genotypic lineage switch of a lymphoma with shared chromosome translocation and T-cell receptor gamma gene rearrangement." Jpn J Cancer Res. 83. 465-476 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takagi N, et al.: "A phenotypic and genotypic study of three node-based, low-grade peripheral T-cell lymphoma ; angioimmunoblastic lymphoma, T zone lymphoma and lymphoepithelioid lymphoma." Cancer. 69. 2571-2582 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S, et al.: "Peripheral T-cell lymphoma of AILD type involving gastrointestinal tracl. A morphologic, phenotypic and genotypic study." Acta pathol Jpn. 42. 141-149 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takagi N, et al.: "Malignant lymphoma of mucosaasscciated lymphoid tissue arising in the thymus of the patient with Sjogren's syndrome. A morphologic, phenotypic and genotypic study." Cancer. 69. 1347-1355 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi