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1993 Fiscal Year Final Research Report Summary

Identification of anti-HTLV-I neutralizing antibodies and epitopes

Research Project

Project/Area Number 04670277
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionKagoshima University

Principal Investigator

SONODA Shunro  Kagoshima University Virology Professor, 医学部, 教授 (40036463)

Co-Investigator(Kenkyū-buntansha) YASHIKI Shinji  Virology Assistant, 医学部, 助手 (40182315)
FUJIYOSHI Toshinobu  Virology Assoc.Professor, 医学部, 助教授 (50173480)
Project Period (FY) 1992 – 1993
KeywordsHTLV-I / Mother-to-child transmission / Transplacental antibody / Neutralizing antibody / Anti-env-antibody
Research Abstract

We have reported a role of anti-HTLV-I maternal antibodies to protect children from HTLV-I infection after birth (Int.J.Cancer 49, 673-677, 1991).
The present study aimed to investigate the antibodies to neutralize HTLV-I and the correlation with anti-envelope antibodies. The mnaternal antibodies disappeared by 3-9 moths after birth. It was confirmed that 30% of chilren born to HTLV-I carrier mothers were infected with HTLV-I when they received breast milk over 6 months after birth (Asia-Occeanian J.Obstet.Gynecol.18, 371-377, 1992).
All the children who were not infected with HTLV-I (5/5 cases) shoed poitive neutralizing antibody as well as anti-envelope antibody, while those infected with HTLV-I showed incosistent results of neutralizing a antibodies (4/5 cases) and anti-envelope antibodies (1/5 cases).
These results suggested that the presence of anti-envelope antibody might be important for protecting HTLV-I infection. The neutralizing antibodies appeared to react with a variety of epitopes which might be composed of envelopes and non-envelope consituents, the former being the major target of protective antibody and the latter serving an uniquetarget to inhibit HTLV-I replication. The role of anti-envelope antibody is now under confirmation by using serum samples obtained from various ethnic groups other than Japanese (AIDS Res Human Retroviruses 10, 97-101, 1994).

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] T.Oki,M.Yoshinaga,S.Sonoda,and Y.Nagata.: "A sero-epidemiology study on mother-to-child transmission of HTLV-I in southern Kyusyu,Japan." Asia-Occeania J.Obstet.Gynecol.18. 371-377 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Fujino,T.Fujiyoshi,S.Sonoda,Y.Nagata et al.: "HTLV-I transmission from mother to fetus via placenta." Lancet. ii. 1157-1158 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Setoyama,Y.Katahira,H.Tozawa,S.Sonoda.et al.: "Expression of human T-cell lymphotropic virus type-I gene products in the short-term cultured skin tissues of an adult T-cell leukemia/lymphoma patient with cutaneous manifestations." J.Dermatol.19. 133-139 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Fujiyama,T.Fujiyoshi,K.Tajima,S.Sonoda et al.: "A new endemic focus of HTLV-II carriers among Orinoco natives in Colombia." J.Infect.Dis.168. 1075-1077 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 園田俊郎: "成人T細胞白血病ウイルス「HTLV-I」" ウイルス. 43. 93-100 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] V.Zaninovic,F.Sanzon,K.Tajima,S.Sonoda et al.: "Geographic independence of HTLV-I and HTLV-II foci in the Andes highland the Atlantic Coast and Orinoco of Colombia." AIDS Res.Human Retroviruses. 10. 97-101 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Sonoda,B.Arce-Gomez,M.L.Satz et al.: "HLA1991" Oxford University Press.(eds.K.Tsuji,M.Aizawa,T.Sasazuki), 720(12) (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Sonoda: "Advances in Adult T-cell Leukemia and HTLV-I Research" Japanese Cancer Association(eds Takatsuki,Hinuma,Yoshida), 261(12) (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Oki, M.Yoshinaga, S.Sonoda, and Y.Nagata.: "A sero-epidemiologystudy on mother-to-child transmission of HTLV-I in southern Kyusyu, Japan." Asia-Occeania J.Obstet.Gynecol. 18. 371-377 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Fujino, T.Fujiyoshi, S.Sonoda, Y.Nagata, et al.: "V-I Transumission from mother to fetus via placenta." Lancet. ii. 1157-1158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Setoyama, Y.Katahira, H.Tozawa, S.Sonoda, et al.: "Expression of human T-cell lymphotropic virus type-I gene products on the short-term cultured skin tissues of an adult T-cell leukemia/lymphoma patient with cutaneous manifestations." J.Dermatol.19. 133-139 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Fujiyama, T.Fujiyoshi, K.Tajima, S.Sonoda, et al: "A new endemic focus of HTLV-IIcarriers among Orinoco natives in Colombia." J.Infect.Dis.168. 1075-1077 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] V.Zaninovic, F.Sanzon, K.Tajima S.Sonoda, et al.: "Geographic independence of HTLV-I and HTLV-II foci in the Andes highland the Atlantic Coast and Orinoco of Colombia." AIDS.Res.Human Retrovirus. 10. 97-101 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sonoda, B.Arce-gomez, M.L.Satz, et al.: Oxford UniversityPress.(eds.K.Tsuji, M.Aizawa, T.Sasazuki). HLA 1991, 720 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sonoda: Japanese Cancer Association.(eds Takatsuki, Hinuma, Yoshida).Advances in Adult T-cell Leukemia and HTLV-I Research., 261 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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