1993 Fiscal Year Final Research Report Summary
Follow-up studies on protective effects of breast feeding against rotavirus infection in infants.
| Project/Area Number |
04670335
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | Yokohama City University |
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Principal Investigator |
SODA Kenji Yokohama City University, School of Medicine, Department of Public Health, Professor, 医学部, 教授 (80154706)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Seiichi Yokohama City University, School of Medicine, Department of Public Health, Lectu, 医学部, 講師 (90106302)
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| Project Period (FY) |
1992 – 1993
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| Keywords | ROTAVIRUS / GASTROENTERITIS / IgA-ANTIBODY IN COLOSTRUM / ELISA / BREAST-FEEDING |
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| Research Abstract |
To elucidate the protective effect of breast-feeding against diarrhea in infants, we measured specific IgG antibodies in maternal serum and specific IgA antibodies in colostrum to human rotavirus (HRV, Wa-strain). And we studied the morbidity of "winter gastroenteritis" in infants using the questionaires on the infant's history of diarrhea and the period of breast feeding. The results were summarized as follows :
1) HRV antibodies in maternal serum and colostrum.
Positive rates of HRV antibodies in maternal serum and colostrum were almost similar, 92% and 91% respectively. Mean levels of antibodies to HRV in maternal and cord sera and colostra of second-paras and multiparas were significantly higher than those of primiparas. Higher titer levels were also observed in colostra of multiparas than those of primiparas. Mean levels of HRV-specific antibodies were significantly higher in maternal sera of multiparas within 2 or 3 years after delivery than those of primiparas. However, mean levels of antibodies of multiparas with 4 years and more interval of delivery were similar to those of primiparas. These results suggest that mother's HRV antibodies might be increased by re-infection with HRV from their children.
2) Incidence rates of "winter gastroenteritis" in infants.
Percentages of the infants fed with breast-milk and formula-milk were 38% and 7%, respectively. Fifty-five percent of the infants received mixed feeding. Of the 470 infants, 47(10%) were affected with winter gastroenteritis. The morbidity of "winter gastroenteritis" before 1 year old in infants received with formula-milk alone were higher than that of infants with long period (over 4 months) breast-feeding. Most of mothers possessed anti-rotaviral antibodies in their colostra which were transfered to their infants by breast feeding. The present findings suggested that long period breast-feeding was effective against HRV infection in infants.
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