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1993 Fiscal Year Final Research Report Summary

Follow-up studies on protective effects of breast feeding against rotavirus infection in infants.

Research Project

Project/Area Number 04670335
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionYokohama City University

Principal Investigator

SODA Kenji  Yokohama City University, School of Medicine, Department of Public Health, Professor, 医学部, 教授 (80154706)

Co-Investigator(Kenkyū-buntansha) ICHIKAWA Seiichi  Yokohama City University, School of Medicine, Department of Public Health, Lectu, 医学部, 講師 (90106302)
Project Period (FY) 1992 – 1993
KeywordsROTAVIRUS / GASTROENTERITIS / IgA-ANTIBODY IN COLOSTRUM / ELISA / BREAST-FEEDING
Research Abstract

To elucidate the protective effect of breast-feeding against diarrhea in infants, we measured specific IgG antibodies in maternal serum and specific IgA antibodies in colostrum to human rotavirus (HRV, Wa-strain). And we studied the morbidity of "winter gastroenteritis" in infants using the questionaires on the infant's history of diarrhea and the period of breast feeding. The results were summarized as follows :
1) HRV antibodies in maternal serum and colostrum.
Positive rates of HRV antibodies in maternal serum and colostrum were almost similar, 92% and 91% respectively. Mean levels of antibodies to HRV in maternal and cord sera and colostra of second-paras and multiparas were significantly higher than those of primiparas. Higher titer levels were also observed in colostra of multiparas than those of primiparas. Mean levels of HRV-specific antibodies were significantly higher in maternal sera of multiparas within 2 or 3 years after delivery than those of primiparas. However, mean levels of antibodies of multiparas with 4 years and more interval of delivery were similar to those of primiparas. These results suggest that mother's HRV antibodies might be increased by re-infection with HRV from their children.
2) Incidence rates of "winter gastroenteritis" in infants.
Percentages of the infants fed with breast-milk and formula-milk were 38% and 7%, respectively. Fifty-five percent of the infants received mixed feeding. Of the 470 infants, 47(10%) were affected with winter gastroenteritis. The morbidity of "winter gastroenteritis" before 1 year old in infants received with formula-milk alone were higher than that of infants with long period (over 4 months) breast-feeding. Most of mothers possessed anti-rotaviral antibodies in their colostra which were transfered to their infants by breast feeding. The present findings suggested that long period breast-feeding was effective against HRV infection in infants.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 曽田研二 他: "乳児嘔吐下痢症における母乳哺育の予防効果に関する追跡調査" 日本公衆衛生学雑誌. (予定). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KENJI,SODA, et al.: "FOLLOW-UP STUDIES ON PROTECTIVE EFFECTS OF BREAST-FEEDING AGAINST ROTAVIRUS INFECTION IN INFANTS." JAPAN J.PUBLIC HEALTH.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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