• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

Clinical study for the pathogenesis of idiopathic chronic pancreatitis -- Analysis on the pathogenesis of familial chronic pancreatitis using the molecular biological methods

Research Project

Project/Area Number 04670403
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTohoku University

Principal Investigator

KOIZUMI Masaru  Tohoku Univ. School of Medicine, Lecturer, 医学部・附属病院, 講師 (40111281)

Co-Investigator(Kenkyū-buntansha) SHIMOSEGAWA Tooru  Tohoku Univ. School of Medicine, Assistant Professor, 医学部・附属病院, 助手 (90226275)
Project Period (FY) 1992 – 1993
KeywordsChronic pancreatitis / Hereditary disease / Molecular biology
Research Abstract

To investigate the pathogenesis of chronic pancreatitis(CP), we determined what kind of genetic abnormality affected the familial CP.We reviewed the reports of young pancreatitis patients and cases of pancreatic disorders in a family. One hundred five patients from 38 families with two and more than two cases of CP have been reported in Japan. There were 56 hereditary CP patients from 15 families, in whom pancreatitis occurred in more than two blood-related persons in over 2 or more generations. Familial CP accounted for 0.7%-1.5% of all cases of CP in Japan. There were 14 patients from 3 families in our clinic. In a kindred having 6 CP patients, we found newly two male patients (29 and 24 years old, two patient's sons) proved by pancreatic calcification and irregular dilatation of the pancreatic duct.
No genetic abnormality in the familial CP has been reported. Analysis on the HLA antigens of cases of brothers with CP showed the co-incidence in locus A, B, C, and DR, i.e., both of them possessing A24, BW52, BW54, CW1, DR2 and DR4. One out of four pairs os child and parent in one kindred revealed the same C- and DR-locus(CW1, CW3, DR4, DRW9). Familial CP in our clinic has an increased frequency of the HLA types DR-2. There is no strong relationship between HLA and etiological factors of CP.We think the defensive mechanism plays the mafor role of developing pancreatitis. Genomic DNA was prepared from peripheral leukocytes and digested with EcoRI.HindIII, BamHI, *and StagI.Southern blot analysis revealed neither a rearrangement nor a gross delection of pancreatic secretory trypsin inhibitor(PSTI) and Reg genomic DNA of affected members of two families. Four exons of PSTI gene amplified by polymerase chain reaction(PCR) from genomic DNA was directly sequenced. One single-base change in the PSTI gene of familial CP was observed. But we have not confirmed this region influenced the synthesis of protein.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 金澤義彦,小泉勝 他: "同一のHLA抗原を示し、兄がpancrea divisumであった遺伝性膵炎の1兄弟例" 膵臓. 7. 175-181 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小泉勝 他: "膵炎と糖代謝" 肝胆膵. 24. 442-450 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimosegawa T,et al.: "Histochemical demonstration of NADPH-diaphorase activity a marker for nitric oxide syntase,in neurons of the rat pancreas." Neuroscience Letters. 148. 67-70 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高野英昭 他: "石灰化慢性膵炎兄弟例の経過観察中にその息子たちに膵炎が発症した遺伝性膵炎の一家系" 日消会誌. 90. 933 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koizumi M: "Alcohol consunption and pancreatic disorders in Japan." Asian Med J. 36. 643-651 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小泉勝 他: "家族性慢性膵炎" 胆と膵. 15(6). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 下瀬川徹,小泉勝 他(分担): "消化器疾患の防御機構〈3〉 膵疾患における膵再生蛋白の意義" 正宗研.中澤三郎編 現代医療社, (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小泉勝: "膵臓病学〈竹内正編集〉特発性膵炎" 南江堂, 563(18) (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimosegawa, H.et al: "Hisochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide systhetase, in neuron of the rat pancreas" Neurosci. Lett.147. 67-70 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koizumi, M.: "Alcohol consumption and pancreatic disorders in Japan" Assian Med. J.36. 643-651 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koizumi, M.et al: "Familial chronic pancreatitis (Japanese)" Tan to Sui.15(6). (1994)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi