1993 Fiscal Year Final Research Report Summary
New autocrine agent in hepats cytes and its role
| Project/Area Number |
04670414
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | University of Tokyo |
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Principal Investigator |
MINE Tetsuya Fourth Department of Internal Mediune, University of Tokyo Assistant Professor, 医学部(分), 助手 (20157572)
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| Project Period (FY) |
1992 – 1993
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| Keywords | Activin A / TGF beta / Ba chain / Cytoplasmic free calciom concentration / PTX / growth factor / Inhibition of growth / auto crine |
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| Research Abstract |
I firstly demonstrated that activin A plays a important role in hepatic metabolism, previously. There fore, I started to identify the role of activin A except the effect of hepatic metabolism. Firstly, it was demonstrated that activin A inhibits the proliferation of hepats cytes. Second, activin A seems to be produced by hepatscyles and hepatscytes possesses own specific receptor and sercne thieome hinase. Furthermore, we demonstrated sipal trans duction of activin A in hepatscytes, Activin A activates Phospholipase Cr and promotes the production of inositol tris phosyhates. So, activin A increases the cytsplasmi free calcium concentration. These signal transduction systems were blocked by pertussis toxin.
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