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1993 Fiscal Year Final Research Report Summary

Regulation of heterologons intercellular communication in gastric epithebal cells

Research Project

Project/Area Number 04670415
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionFourth Department of Internal Medicine, University of Tokyo School of Medicine

Principal Investigator

AKIMOTO Kimihiko  Fourth Department of Internal Medicine, University of Tokyo Assistant Professor, 医学部(分), 助手 (70201283)

Co-Investigator(Kenkyū-buntansha) MINE Tetsuya  Fourth Department of Internal Medicine, University of Tokyo Assistant Professor, 医学部(分), 助手 (20157572)
Project Period (FY) 1992 – 1993
Keywordsconnexin / conncxon / gap junction / cultured rabbit gastric epethelial cells / cyclic AMP / Ca^<2+> / TPA / c kinase
Research Abstract

The gap jimction is a structure composed of intercellular channils that permit direct commurication by serving as passages for iono and small molecules between cells. Each gap junctional channels is composed of cornexon, forming a hemichannel in each of the joined membranes. In the present study, (1) Apperance of connexin in ulcer diseases (2) Apperance of connexin in experimental ulcer (3) regulation of gap jimction were inoestigated. Briefly, in chione ulcer, apperince of connexin 32,43, which was determined by using wester blotting of anti connexin 32,43 antibody, was abolished. In experimental designs, chromc ulcer wan madl, by using acetoacetate in rats. Appearences of conexin 32,43 were also abolished in ulcer. Finally, by using cultured rabbit gavtric macosa, regulation of intercellular comminucation was investigated. JBMX,forskslin and isoprotanenolincreased the production of cyclic AMP and increased the capacity of intercellular comminication. Carbacol and iononyan increased the cytoplamic free calcium concentration. From these data, in the gatric mcona, gapuinction plays an important role in glneretion of chronic gaspic ulceration and are regulated by some ligands.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communictation of gap junction of cyclic AMP and Ca^<2+> incultured raffit gastric epithelial cells." Excerpta Medica. 9. 214-219 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured raffit gastric epithclial cells." Excerpta Medica. 10. 191-194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuya Mine et al.: "Intercellular communication regulation at the gap junction by cyclic AMP and Ca^<2+> incultured raffit gastric epithelial cells." Proceeding of IMGJ. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication of gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells" Excerpta Medica. 9. 214-219 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuya Mine et al.: "Regulation of intercellular communication at gap junction by Ca^<2+> in cultured rabbit gastric epithelial cells" Excerpta Medica. 10. 191-194 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuya Mine et al: "Intercellular communication regulation at the gap junction by cyclic AMP and Ca^<2+> in cultured rabbit gastric epithelial cells" Procceding of IMGJ. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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