1993 Fiscal Year Final Research Report Summary
Investigation of Ischemic Neuronal Death and Heat Sensitive Factor
| Project/Area Number |
04670502
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
MINAMISAWA Hiroaki Nippon Medical School, Second Department of Internal Medicine, Assistant, 医学部, 助手 (70200087)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHI Akiro Nippon Medical School, Second Department of Internal Medicine, Professor, 医学部, 教授 (50089645)
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| Project Period (FY) |
1992 – 1993
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| Keywords | cerebral ischemia / hypothermia / hyperthermia / delayd nueronal death / 熱誘導蛋白質(ヒートショックプロテイン) / ピルビン酸脱水素酵素 |
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| Research Abstract |
The present summary of the investigation seeks to clarify the factors depending on brain temperatures which influence ischemic brain damage. The results obtained during this research (04670502), hypothermia reduced the acidification which was recorded by NMR as pH, after complete ischemia in the brain cortex. And hyperthermia accelerate the acidification in the cotex. Brain temperature may primarily influence neuronal membrane permeability and ion fluxes. We are further investigating the factors i.e.induction of heat shock protein, immediate early gene, and precursor proteins and activity of pyruvate dehydrogenase in thecerebral cortex after complete ischemia.
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