1993 Fiscal Year Final Research Report Summary
EXPERIMENTAL STUDY OF VENTRICULAR REMODELLING AFTER MYOCARDIAL INFARCTION
| Project/Area Number |
04670530
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | MIE UNIVERSITY |
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Principal Investigator |
YAMAKADO Tetsu MIE UNIVERSITY,UNIVERSITY HOSPITAL,LECTURER, 医学部・附属病院, 講師 (40122121)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masaaki MIE UNIVERSITY,FACULTY OF MEDICINE,ASSISTANT, 医学部, 助手 (00223181)
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| Project Period (FY) |
1992 – 1993
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| Keywords | MYOCARDIAL INFARCTION / REMODELLING / VENTRICULAR FUNCTION |
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| Research Abstract |
To investigate left ventricular (LV) remodelling after myocardial infarction (MI), we serially obtained LV pressures and LV grams 15 minutes, 3 hours, 48 hours, 1 week, 2 weeks and 4weeks after MI.MI was produced by occlusion of left anterior descending coronary artery for 3 hours. LV pressure was measured with a tip manometer. LV grams were analyzed quantitatively by tracing LV silhouttes. Results were as follows :
Conclusion. LV after MI results in remodelling of structure and function. Dilatation of infarct area occurred within 2 days after MI,and further dilatation was not observed. In contrast, Non-infarct area progressively dilated up to 1 week. We are now studying LV remodelling in LV hypertrophy.
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