• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

Experimental Research about Etiology of Long QT Syndrome and Torsades dePointes

Research Project

Project/Area Number 04670552
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionWakayama Medical College

Principal Investigator

UENO Yuji  Wakayama Medical College, Department of Cardiology, Associated Professor, 医学部・循環器内科, 助教授 (50151824)

Co-Investigator(Kenkyū-buntansha) HOSHIYA Hironobu  Wakayama Medical College, Department of Cardiology, Assistant, 医学部・循環器内科, 助手 (00244723)
Project Period (FY) 1992 – 1993
KeywordsLong QT Syndrome / Early After Depolarization / Monophasic Action Potential / Torsades de Pointes / Quinidine / Ansae-Subclaviae Stimulation
Research Abstract

The purpose of this study is to clarify the mechanisms responsible for QTU abnormality and Torsades de Pointes (Tdp) in patients with congenital and acquired long QT syndrome (LQTS). We recorded body surface electrocardiogram (ECG) and monophasic action potential (MAP) in vivo heart using the contact electrode technique, in patients with congenital LQTS and in dogs, and evaluated QT interval (QT), MAP duration at 90% repolarization (MAP90) and early after depolarization (EAD).
1. Clinical evaluation : ECGs and MAPs were obtained from the right and left ventricular endocardium (RV-and LV-MAP) in 4 patients with congenital LQTS (LQTS group : 12 recording sites) and in 3 patients with sick sinus syndrome (control group : 9 recording sites). EADs were recorded in all of the LQTS group at 4 recording sites, but not in the control group. After isoproterenol (Isp) infusion QT and MAP90 were significantly prolonged (p<0.02) associated with EAD enlargement in the LQTS group, whereas these change … More s were not found in the control group.
2. Effects of ansae subclaviae stimulation on ECG and MAP in dogs : We recorded ECGs, RV-MAPs and LV-MAPs in 9 adult mongrel dogs before and after left, right and bilateral ansae subclaviae stimulation (LAS,RAS and BAS). QT and MAP90 were significantly shortened after LAS and BAS, but not after RAS, EADs were not recorded before and after any types of ansae subclaviae stimulation (LAS,RAS and BAS).
3. Quinidine induced QTU abnormalities and EADs in dogs : ECGs, LV-MAPs and RV-MAPs were recorded before and after quinidine (Qi) infusion in 9 adult beagle dogs, and the effect of BAS and verapamil (Ver) infusion on EAD were evaluated EADs were not recorded during control state at any MAP recording sites. 60 minutes after Qi infusion, QT,LV-MAP90 and RV-MAP90 were significantly prolonged (p<0.01), and EADs were recorded 6 recording sites. EADs were depended upon bradycardia and enlarged after BAS but diminished after Ver infusion.
Conclusion : EADs play the important role in the etiologies of QTU abnormalities and Torsades de Pointes in patients with congenital and quinidine-induced LQTS. Less

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Mohara,O.,Hoshiya,H.,Veno,Y.et al.: "Vasopressin modities post junctional adrenergic Vasoconstriction in dehydrated dogs." Ther.Res.13. 124-128 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 半田暁司,上野雄二,他: "当施設における急性心筋梗塞の臨床成績および死因の検討" 和歌山医学. 44. 101-104 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上野雄二: "臓器障害,合併症をもつ高血圧の治療" 臨床と研究. 70. 1911-1913 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 星屋博信 他: "急性心筋梗塞を併発し、冠動脈造影上血栓によると思われる不整な陰影欠損像を示した真性多血症の1例" 心臓. 23. 912-917 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 星屋博信 他: "不整脈の成因と診断" ハートナーシング. 2. 77-87 (1989)

    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi