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1993 Fiscal Year Final Research Report Summary

EXERCISE THERAPY IN CHILDREN WITH INSULIN-DEPENDENT DIABETES MELLITUS

Research Project

Project/Area Number 04670585
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionYAMANASHI MEDICAL UNIVERSITY

Principal Investigator

AMEMIYA Shin  YAMANASHI MEDICAL UNIVERSITY, ASSISTANT PROFESSOR, 医学部, 講師 (10118903)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Kouji  YAMANASHI MEDICAL UNIVERSITY, ASSISTANT, 医学部, 医員
SAWANOBORI Emi  YAMANASHI MEDICAL UNIVERSITY, ASSISTANT, 医学部, 医員
ISHIHARA Toshihide  YAMANASHI MEDICAL UNIVERSITY, ASSISTANT, 医学部, 医員
HIGASHIDA Kosuke  YAMANASHI MEDICAL UNIVERSITY, RESEARCH ASSOCIATE, 医学部, 助手 (60173142)
Project Period (FY) 1992 – 1993
KeywordsINSULIN-DEPENDENT DIABETES MELLITUS / EXERCISE / CHILD / TREADMILL / RENIN / OXYGEN CONSUMPTION / INSULIN-LIKE GROWTH FACTOR / ENERGY EXPENDITURE / FOOD SUPPLEMENT
Research Abstract

Exercise therapy has been difficult to be introduced in children with insulin-dependent diabetes mellitus (IDDM), because the insulin injected subcutaneously produced unphsiologic metabolic mellieu in those patients, so that they are suffered from hypoglycemia during or after exercise. These difficulties were investigated in terms of cardio-respiratory fitness, metabolic stability, and renal hemodynamics. We found they were well tolerated during acute load by a treadmill running, although diabetic girls tended to show less maximal oxygen consumption and children with IDDM were revealed to have low activation of rennin-aldosteron system. Since they did not show significant metabolic disturbance during excercise, and showed liner corelationship between oxygen consumption and heart rate, a portable heart rate monitor was applied to them during various sport activity. Supplemental foods according to expected energy consumption were calculated on every 30 minutes basis.
The contraindication to a sport activity has been difficult in the evaluation. The morning hyperglycemia and ketonuria have been criterion to inhibit to sports. Our results revealed, however, clearly that hyperglycemia itself showed good correlation to night-time hypoinsulinemia in the liver suggested by serum levels of insulin-like-growth factor binding-protein (IGFBP-1). The mild ketonuria were accounted for the same mechanisms. So that they were well adjusted by a ordinal breakfast and insulin injection, unless they showed other significant symptoms of illness. The long-term effects of accustomed exercise have been evalutated in progress in terms of cardio-respiratory fitness and glycemic controls. The chronic complication such as a diabetic nephropathy cannot yet be assessed, although mild malfunction of renin-aldosteron system may be evaluated along with a accustomed sports.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 雨宮 伸: "インスリン依存型糖尿病におけるスポーツの意義と課題" 小児科. 33. 735-744 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 東田 耕輔: "糖尿病早期腎症における運動負荷時の腎血行動態の変化について" 日本小児腎臓病学会雑誌. 5. 333 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石原 俊秀: "小児インスリン依存型糖尿病におけるトレッドミル負荷による運動の運野能力の評価とその適用" 糖尿病. 36. 297 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐野 恵美: "IDDM小児における運動の腎血流動態に与える影響" 糖尿病. 36. 292 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 浩司: "IDDM児の運動療法導入における補食量算定の問題点" 糖尿病. 36. 136 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amemiya,Shin: "Increased IGFBP-1 levels relating to low IGF-1 in diabetic children" Clin Pediatr Endocrinol. 3(印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amemiya S: "Exercise in children with insulin-deprndent diabetes mellitus." Pediatrics of Japan. 33. 735-744 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amemiya S: "Increased IGFBP-1 levels relating to low IGF-1 in diabetic children." Clin Pediatr Endocinol. 3, (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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