1993 Fiscal Year Final Research Report Summary
Morphological and hemodynamic changes of the fetal heart : chronological evaluation from fetus to newborn
| Project/Area Number |
04670627
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
KATO Hirohisa Kurume University, Pediatrics, Professor, 医学部, 教授 (30080724)
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| Co-Investigator(Kenkyū-buntansha) |
MAENO Yasuki Kurume University, Med.Assistant, 医学部, 助手 (90248401)
MIYAKE Takumi Kurume University, Med.Assistant, 医学部, 助手 (80229814)
KIYOMATSU Yumi Kurume University, Med.Assistant, 医学部, 助手 (10214917)
TOYODA On Kurume University, Med.Assistant, 医学部, 助手 (40237152)
RIKITAKE Noriko Kurume University, Med.Assistant, 医学部, 助手 (40201868)
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| Project Period (FY) |
1992 – 1993
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| Keywords | fetal echocardiography / intrauterine diagnosis / fetal arrhythmia / intrauterine treatment / fetal pharmacokinetics |
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| Research Abstract |
1.Prenatal diagnosis of fetal stuctural heart anomaly and fetal arrhythmia Fetal echocardiography was performed for 1080 cases. Thirty-four cases of structural heart anomaly and 44 cases of fetal arrhythmia was diagnosed and managed perinatal period.
2.Fetal arrhythmia and fetal therapy.
(1)In fetal bradycardia group, fetal therapy was performed in 3 cases but all failed.
(2)In fetal tachycardia group, digoxin or verapamil was administered transplacentally in 5 cases, and 4 was successfully treated.
3.Structural heart anomaly ; prenatal diagnosis and perinatal management.
(1)In the tricuspid valve dysplasia case, we could proved prenatal development of pulmonary valve stenosis and functional pulmonary valve obstruction.
(2)Digoxin was administered transplacentally for fetal hydrops caused by CHD, and successfully teated.
4.Transplacental pharmacokinetics of digoxin and flecainide in pregnant rabbits and fetuses.
(1)Although the placental transfer of digoxin occurred immediately, equilibrium between maternal and fetal serum consentration.
(2)Flecainide was transferred the placenta rapidly and equilibrium between maternal and fetal serum concentration occurred very fast.
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