1993 Fiscal Year Final Research Report Summary
Development of the novel PET imaging technology for diagnosis of the brain functional abnormality such as dementia
| Project/Area Number |
04670657
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
ONO Shuichi Tohoku University, Institute of Development, Aging and Cancer, Assistant, 加齢医学研究所, 助手 (00240664)
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| Project Period (FY) |
1992 – 1993
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| Keywords | Brain / High order brain function / Dementia / PET / Brain glucose metabolism / Cerebral blood flow |
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| Research Abstract |
The brain glucose metabolism of young healthy volunteers was studied using the FDG PET technique with and without visual stimulation. We found the intersubject alterations of rate constants, as well as that of cerebral metabolic rates for glucose (CMRglc), in the primary visual cotex during the activated state. Also we found high RI concentration indicating high activity of the frontal lobe during the simple calculation task. The glucose metabolism was measured as well on old volunteers and dementia patients. These data are now under analysis to investigate the alterations of glucose metabolism during aging or by dementia. From these PET data, we developed a novel method to avoid frequent arterial blood sampling for calculation of CMRglc with the autoradiography method. Individual plasma time-activity curves were standardized according to injected RI dose and averaged. Then we calibrated this standardized curve with actual plasma RI concentration of two time points and calculated CMRglc using this calibrated curve. These calculated values of CMRglc seemed as reliable as those from actual plasma time-activity curves. In the cerebral blood flow (CBF) studies using the ^<15>O-CO_2 continuous inhalation method, at first we confirmed detection of activation in the primary visual cortex with this method during the visual stimulation. Then we investigated activation by olfactory and gustatory stimulations with this method. We found significant increase of CBF in the limbic system by these stimulations. Because this particular brain region is known to be deeply related to neuropathological alterations of dementia, these findings are of importance for differential diagnosis of dementia from normal aging or its earlier diagnosis.
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Research Products
(7 results)
