• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

SURGICAL TREATMENT OF CHRONIC ATRIAL FIBRILATION BY EPICARDIAL LASER PHOTOCOAGULATION

Research Project

Project/Area Number 04670824
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionSHIGA UNIVERSITY OF MEDICAL SCIENCE

Principal Investigator

ONOE Masahiko  SHIGA UNIVERSITY OF MEDICAL SCIENCE, SECOND DEPARTMENT OF SURGERY, ASSISTANT PROFESSOR, 医学部, 助手 (90214197)

Co-Investigator(Kenkyū-buntansha) SUGITA Takaaki  SHIGA UNIVERSITY OF MEDICAL SCIENCE, SECOND DEPARTMENT OF SURGERY, ASSISTANT PRO, 医学部, 助手 (30235882)
WATARIDA Shoji  SHIGA UNIVERSITY OF MEDICAL SCIENCE, SECOND DEPARTMENT OF SURGERY, ASSISTANT PRO, 医学部, 助手 (90191816)
MORI Atsumi  SHIGA UNIVERSITY OF MEDICAL SCIENCE, SECOND DEPARTMENT OF SURGERY, PROFESSOR, 医学部, 教授 (80026971)
Project Period (FY) 1992 – 1993
KeywordsNd-YAG laser / Atrial fibrillation / Surgical treatment / Epicardial approach / Right atrial isolation
Research Abstract

For treatment of chronic atrial fibrillation and other refractory supraventricular tachycardias, right atrial isolation by epicardial YAG laser photocoagulation without cardiopulmonary bypass was studied. In five mongrel dogs, following median thoracotomy, intraoperative electrophysiological study was performed. Epicardial laser photocoagulation was applied to the right atrium and encircled the right atrial free wall. Postoperatively, electrophysiological study confirmed that all dogs had normal sinus rhythm and that the free wall of the right atrium was electrically isolated from the remainder of the heart. Histologically subendocardial thrombus was recognized at the photocoagulation sites on the right atrial free wall. Myocardial blood flow of the right atrium was reduced from the pre-isolation value of 180.1 ml/min/100g to 148.7ml/min/100g after the isolation procedure, but the difference was not significant. The ATP concentration in the atrial tissues was significantly reduced from 1.59 mumole/g before electrical isolation to 0.29 mumole/g after electrical isolation. It is concluded that the right atrial isolation by epicardial laser irradiation could be an alternative non-pharmacologic treatment of supraventricular tachycardias ariseing in the right atrium.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] M.ONOE: "Surgical treatment of the Wolff-Parkinson-White syndrome in children" Cardiovascular Surgery. 1. 569-572 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onoe M, Mori A, Watarida S, Sugita, T.Shiraishi S, Nojima T, Fujiseki Y, Tabata R, Matsuno S: "Surgical treatent of the Wolff-Parkinson-White syndrome in children." Cardiovascular Surgery. 1. 569-572 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi