1994 Fiscal Year Final Research Report Summary
The research of cardioprotective effects of nucleoside transport inhibition.
| Project/Area Number |
04670832
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
MASUDA Munetaka Kyushu Univ., Fuculty of Medicine, Assistant Professor, 医学部, 講師 (10190365)
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| Co-Investigator(Kenkyū-buntansha) |
KOUNO Hiroyuki Kyushu Univ., Fuculty of Medicine, Assistant Professor, 医学部, 講師 (80178227)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Nucleoside transport inhibition / Adenosine / Acadesine |
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| Research Abstract |
First, we investigated whether uncleoside transport inhibitor (NTI) have cardioprotective effect in case that hearts were not maintained hypothemia completely and ATP was broken down. In case myocardial ATP degradate due to poor myocardial protection, NTI has a cardioprotective effect related to acculation of endogeneous addenosine.
Second, we tested the cardioprotective effect of the combined use of acadesine and NTI on the deep hypothermic ischemia. Individual use of these agents did not work effectively, but the combined use of both acadesine and NTI increased the endogenous adenosine and improved myocardial protection.
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