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1993 Fiscal Year Final Research Report Summary

IMMUNOTHERAPY OF MALIGNANT BRAIN TUMORS USING OK-432-ACTIVATED MONONUCLEAR CELLS COMBINED WITH HUMAN MONOCLONAL ANTIBODY AGAINST CANCER

Research Project

Project/Area Number 04670866
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionSAGA MEDICAL SCHOOL

Principal Investigator

ABE Masamitsu  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (20136427)

Co-Investigator(Kenkyū-buntansha) KIHARA Shunichi  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, LECTURER, 医学部, 助手 (30253610)
TABUCHI Kazuo  SAGA MEDICAL SCHOOL, FACLUTY OF MEDICINE, PROFESSOR, 医学部, 教授 (50116480)
Project Period (FY) 1992 – 1993
KeywordsGlioma / MHC / Immunotherapy / Monoclonal antibody / Cytokine
Research Abstract

Local administration of OK-432-activated killer (OK-AK) cells has been effective in most patients with malignant brain tumor. In this therapy natural killer(NK) cells are the main effector cells. Recently the inverse correlation between major histocompatibility (MHC) class I expression and susceptibility of target cells to NK cell-mediated lysis has been reported. We exmained the sensitivity of human glioblastoma cells under MHC class I-expressing and the non-expressing conditions.
Our results showed that OK-AK cells exclusively lysed the human gliobalstoma cells and that the susceptibility of glioblastoma cells to NK lysis was markedly reduced by the expression of MHC class I antigens on their cell surface. Human monoclonal antibody against cancer (CLN-IgG) was bound to malignant gliomans more than to low-grade gliomas. The susceptibility of glioblastoma cells with the expression of MHC class I antigens to NK lysis was improved by the administration of CLN-IgG.
The present results indicate that CLN-IgG may enhance the cytocidal effect of OK-AK cells against malignant gliomas.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 阿部雅光: "先端巨大症とクッシング病に対する定位的陽子線治療" ホルモンと臨床. 40. 110-113 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Momozaki N.: "Suppression of anchorage-independent growth of human glioblastoma by major histocompatibility complex class I genetransfection." J.Neurosurg. 76. 845-849 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田渕和雄: "神経膠腫の癌遺伝子と癌抑制遺伝子" 医学のあゆみ. 161. 420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田渕和雄: "脳腫瘍の遺伝子診断" 脳と神経. 44. 871-879 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tabuchi K.: "Altered structure and expression of the p53 gene in human neuroepithelial tumors." Neurol.Med.Chir.32. 725-732 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田渕和雄: "脳腫瘍の分子生物学的特性" 脳神経外科. 21. 677-696 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Abe M,Kjellberg RN: "Stereotactic proton beam therapy for acromegaly and Cushing disease." Horumon to Rinshou (Jpn). 40. 110-113 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Momozaki N., Oh-uchida M., Tabuchi K., Ikezaki K.and Hori K.: "Suppression of anchorage-independent growth of human glioblastoma by major histocompatibility complex class I gene-transfection." J.Neurosurg.76. 845-849 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tabuchi K.: "Oncogene and tumor suppressor gene of gliomas." Igakuno Ayumi(Jpn). 161. 420 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tabuchi K., Fukuyama K., Mineta T.: "Gene therapy of brain tumors." Brain Nerve(Jpn). 44. 871-879 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tabuchi K., Fukuyama K., Mineta T., Ohuchida M.and Hori K.: "Altered structure and expression of the p53 gene in human neuroepithelial tumors." Neurol.Med.Chir.32. 725-732 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tabuchi K., Shiraishi T.: "Molucular biological characteristics of brain tumor." Neurol.Surg.(Jpn). 21. 677-696 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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