1994 Fiscal Year Final Research Report Summary
PATHOLOGIC PHYSIOLOGY OF HEAT ATROKEIN ANIMALS
| Project/Area Number |
04670932
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | OITA MEDICALUNIBERSITY |
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Principal Investigator |
ODA Shunsuke DEPARTMENT OF ANESTHESIOLOGY ASSOCIATE FELLOW, 医学部, 助教授 (30108328)
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| Co-Investigator(Kenkyū-buntansha) |
IKEBE Haruyoshi DEPARTMENT OF ANESTHESIOLOGY FELLOW, 医学部, 助手 (30202914)
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| Project Period (FY) |
1992 – 1994
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| Keywords | HYPERTHERMIA / BLOOD-VISCOSITY / GLUCOSE TOLERANCE / INSULIN / CEREBRALBLOODFLOW / CEREBRAL PRESSURE |
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| Research Abstract |
THE EFFECT OF INDUCED HYPERTHERMIA UP TO 43ﾟC FOR 60MINUTES WITH WARM WATER ON BLOOD VISCOSITY WAS STUDIED BY USING 12JAPANESE MONKEYS.
ONE MONKEY WAS DIED BUT ELEVEN WERE ALIVE.UPON REA CHING 43ﾟC SYSTOLIC AND DLASTOLICBLOODPREASSURE DECREASED.,
THE BLOOD VISCOSITY UNREMARKABLE CHANGE AS THE BODY TEMPERATURE ROSE TO 43ﾟC,BUT INCREASED AS BODY TEMPERATURE WAS MAINTAINED FOR 60 MINUTES AT 43ﾟC AND SIGNIFICANTLY INCREASED WHEN RETURNED THE NORMALLEVEL.THIS BLOODVISCOSITY CORRELATED INTIMATELY WITH HEMATOCRIT ELEVATION.THE EFFECT OF INDUCED HYPERTHERMIA UP TO 38,40 AND 42ﾟC ON GLUCOSE TOLERANCETEST WAS STUDIED BY USING 8 JAPANESE MONKEYS.THE BODY TEMPERATURE MEASURED WITH THERMOMETERSIN THE ESOPHAGUS.THESE WERE MAINTAINED 38,40 AND 42<plus-minus>0.2ﾟC.GLUCOSE WAS INFUSED 0.5g/kg AND BLOODGLUCOSE,INSULIN AND C-PEPTIDE WERE MEASURED,BLOODGLUCOSE OF 40ﾟC GROUP SHOWS HEIGHER THAN 38ﾟC GROUP.BLOODGUCOSE OF 42ﾟC GROUP WERE SIGNIFICANT HEIGHER 38ﾟC GROUP ON THE OTHERHAND,INSULIN LEVEL OF 40ﾟC GROUP WAS LOWED THAN THAT OF 38ﾟC GROUP BUT THE LEVEL OF 42ﾟC GROUP WAS HEIGHER THAN THE LEVEL OF 38ﾟC GROUP AT 30 MIN.AFTER GLUCOSE INFUSIO
THE EFFECT OF INDUCED HYPERTHERMIA UP TO 43ﾟC FOR 60 MINUTED ON CEREBRO VA SCULAR CIRCULATION AND INTRA CRANIAL PRESSURE WAS STUDIED BY USING 10 MONGREL DOGS.CHANGES IN THE CEREBRO VA SCULAR SYSTEM REVEALED SIGNIFICANT CHANGES IN VBF WERE DETECTED,AND THERE WERE NO SIGNIFICANT CHANGES IN CEREBRAL CORTICAL AND MEDURALBLOODGLOW.NO SIGNIFICANT CHANGES IN CEREBRAL CORTICAL AND MEDURALBLOODGLOW.ICP WAS SIGNIFICANTLY ELEVATED.
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